Evidence map›Paper›PMID 38338777›Full record

ArticleInternational journal of molecular sciences2024

Identification of a Panel of miRNAs Associated with Resistance to Palbociclib and Endocrine Therapy.

Rosalba Torrisi, Valentina Vaira, Laura Giordano, Bethania Fernandes, Giuseppe Saltalamacchia, Raffaella Palumbo, Carlo Carnaghi, Vera Basilico, Francesco Gentile, Giovanna Masci and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Rosalba TorrisiMedical Oncology and Hematology Unit, Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milano, Italy.
Valentina VairaDivision of Pathology, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, 20122 Milano, Italy.ORCID 0000-0003-4416-6216
Laura GiordanoBiostatistic Unit, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milano, Italy.ORCID 0000-0002-9587-7870
Bethania FernandesPathology Department, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milano, Italy.ORCID 0000-0002-4327-1586
Giuseppe SaltalamacchiaMedical Oncology and Hematology Unit, Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milano, Italy.
Raffaella PalumboOncologia Medica IRCCS ICS Maugeri, 27100 Pavia, Italy.
Carlo CarnaghiClinical Trials Unit, Istituto Clinico Humanitas, Centro Catanese di Oncologia, 20072 Catania, Italy.
Vera BasilicoMedical Oncology Unit, Istituto Clinico Mater Domini Humanitas, Castellanza, 21100 Varese, Italy.
Francesco GentileDivision of Pathology, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, 20122 Milano, Italy.
Giovanna MasciMedical Oncology and Hematology Unit, Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milano, Italy.
Rita De SanctisMedical Oncology and Hematology Unit, Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milano, Italy.ORCID 0000-0003-3202-1933
Armando SantoroMedical Oncology and Hematology Unit, Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milano, Italy.ORCID 0000-0003-1709-9492
IRCCS Humanitas Research Hospital · ITHumanitas University · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITHumanitas Mater Domini · ITIstituti Clinici Scientifici Maugeri · ITUniversity of Milan · IT

Funding

Pfizer (Italy) NA
6 · The paper itself

Abstract

We investigated whether we could identify a panel of miRNAs associated with response to treatment in tumor tissues of patients with Hormone Receptor-positive/HER2-negative metastatic breast cancer treated with endocrine therapy (ET) and the CDK4/6 inhibitor (CDK4/6i)i palbociclib. In total, 52 patients were evaluated, with 41 receiving treatment as the first line. The overall median PFS was 20.8 months (range 2.5-66.6). In total, 23% of patients experienced early progression (<6 months). Seven miRNAs (

Indexed as

Breast NeoplasmsMicroRNAsPyridinesAntineoplastic Combined Chemotherapy ProtocolsCyclin-Dependent Kinase 4Erb-b2 Receptor Tyrosine KinasesFemaleHumansPhosphatidylinositol 3-KinasesPiperazinesCyclin-Dependent Kinase 4Erb-b2 Receptor Tyrosine KinasesMicroRNAsMIRN1297 microRNA, humanMIRN324 microRNA, humanMIRN448 microRNA, humanMIRN455 microRNA, humanMIRN877 microRNA, humanpalbociclibPhosphatidylinositol 3-KinasesPiperazinesPyridineshormone receptor positive/HER2 negativemetastatic breast cancermiRNAspalbociclibsTILs

Identifiers

PMID38338777
PMCPMC10855102
OpenAlexW4391231306

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.