Evidence map›Paper›PMID 38338774›Full record

ArticleInternational journal of molecular sciences2024

Safe Procedure for Efficient Hydrodynamic Gene Transfer to Isolated Porcine Liver in Transplantation.

Luis Sendra, Mireia Navasquillo, Eva M Montalvá, David Calatayud, Judith Pérez-Rojas, Javier Maupoey, Paula Carmona, Iratxe Zarragoikoetxea, Marta López-Cantero, María José Herrero and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Luis SendraPharmacogenetics and Gene Therapy Unit, La Fe Health Research Institute, 46026 Valencia, Spain.ORCID 0000-0003-3176-9763
Mireia NavasquilloDepartment of HPB Surgery and Transplantation Unit, Division of General Surgery, University and Polytechnic La Fe Hospital, 46026 Valencia, Spain.
Eva M MontalváDepartment of HPB Surgery and Transplantation Unit, Division of General Surgery, University and Polytechnic La Fe Hospital, 46026 Valencia, Spain.ORCID 0000-0002-8563-1340
David CalatayudDepartment of HPB Surgery and Transplantation Unit, Division of General Surgery, University and Polytechnic La Fe Hospital, 46026 Valencia, Spain.
Judith Pérez-RojasPathology Department, University and Polytechnic La Fe Hospital, 46026 Valencia, Spain.ORCID 0000-0002-6091-0888
Javier MaupoeyDepartment of HPB Surgery and Transplantation Unit, Division of General Surgery, University and Polytechnic La Fe Hospital, 46026 Valencia, Spain.
Paula CarmonaAnesthesia and Resuscitation Service, University and Polytechnic La Fe Hospital, 46026 Valencia, Spain.
Iratxe ZarragoikoetxeaAnesthesia and Resuscitation Service, University and Polytechnic La Fe Hospital, 46026 Valencia, Spain.ORCID 0000-0003-3740-6154
Marta López-CanteroAnesthesia and Resuscitation Service, University and Polytechnic La Fe Hospital, 46026 Valencia, Spain.
María José HerreroPharmacogenetics and Gene Therapy Unit, La Fe Health Research Institute, 46026 Valencia, Spain.ORCID 0000-0002-6042-4185
Salvador F AliñoPharmacogenetics and Gene Therapy Unit, La Fe Health Research Institute, 46026 Valencia, Spain.ORCID 0000-0002-7830-8713
Rafael López-AndújarDepartment of HPB Surgery and Transplantation Unit, Division of General Surgery, University and Polytechnic La Fe Hospital, 46026 Valencia, Spain.
Hospital Universitari i Politècnic La Fe · ESUniversitat de València · ES

Funding

Fundación Mutua Madrileña 2017/0270
6 · The paper itself

Abstract

Although calcineurin inhibitors are very effective as immunosuppressants in organ transplantation, complete graft acceptance remains as a challenge. Transfer of genes with immunosuppressant functions could contribute to improving the clinical evolution of transplantation. In this sense, hydrodynamic injection has proven very efficacious for liver gene transfer. In the present work, the

Indexed as

HydrodynamicsInterleukin-10AnimalsCytokinesHumansInterleukin-1betaInterleukin-6LiverSwineTransforming Growth Factor betaTumor Necrosis Factor-alphaCytokinesInterleukin-10Interleukin-1betaInterleukin-6Transforming Growth Factor betaTumor Necrosis Factor-alphacytokinesgene therapyinterleukin-10naked DNA

Identifiers

PMID38338774
PMCPMC10855839
OpenAlexW4391217920

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.