Evidence map›Paper›PMID 38338761›Full record

ArticleInternational journal of molecular sciences2024

Methylation Patterns of the FKBP5 Gene in Association with Childhood Maltreatment and Depressive Disorders.

Nora L Großmann, Antoine Weihs, Luise Kühn, Susann Sauer, Simone Röh, Tobias Wiechmann, Monika Rex-Haffner, Henry Völzke, Uwe Völker, Elisabeth B Binder and 4 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  4. Review
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  7. Neurobiology of stress · 2025
    Review
  8. Article
  9. Review
  10. From Stress to Synapse: The Neuronal Atrophy Pathway to Mood Dysregulation.International journal of molecular sciences · 2025
    Review
  11. Epigenetic Echoes: Bridging Nature, Nurture, and Healing Across Generations.International journal of molecular sciences · 2025
    Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Nora L GroßmannDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475 Greifswald, Germany.
Antoine WeihsDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475 Greifswald, Germany.ORCID 0000-0002-7113-0027
Luise KühnDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475 Greifswald, Germany.ORCID 0000-0002-0158-8286
Susann SauerDepartment Genes and Environment, Max Planck Institute of Psychiatry, 80804 Munich, Germany.
Simone RöhDepartment Genes and Environment, Max Planck Institute of Psychiatry, 80804 Munich, Germany.
Tobias WiechmannDepartment Genes and Environment, Max Planck Institute of Psychiatry, 80804 Munich, Germany.
Monika Rex-HaffnerDepartment Genes and Environment, Max Planck Institute of Psychiatry, 80804 Munich, Germany.
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.
Uwe VölkerGerman Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, University Medicine Greifswald, 17475 Greifswald, Germany.ORCID 0000-0002-5689-3448
Elisabeth B BinderDepartment Genes and Environment, Max Planck Institute of Psychiatry, 80804 Munich, Germany.
Alexander TeumerDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475 Greifswald, Germany.ORCID 0000-0002-8309-094X
Georg HomuthInterfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany.ORCID 0000-0001-6839-0605
Johanna Klinger-KönigDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475 Greifswald, Germany.ORCID 0000-0003-2287-7914
Hans J GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475 Greifswald, Germany.
Universitätsmedizin Greifswald · DEMax Planck Institute of Psychiatry · DEEmory University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Childhood maltreatment is an important risk factor for adult depression and has been associated with changes in the hypothalamic pituitary adrenal (HPA) axis, including cortisol secretion and methylation of the

Indexed as

Child AbuseDepressive DisorderDNA MethylationTacrolimus Binding ProteinsAdultChildHumansHydrocortisoneHypothalamo-Hypophyseal SystemIntronsPituitary-Adrenal SystemPolymorphism, Single NucleotideTacrolimus Binding Protein 5HydrocortisoneTacrolimus Binding Protein 5Tacrolimus Binding Proteinschildhood maltreatmentcortisoldepressionepigeneticsgeneticsHPAstress

Identifiers

PMID38338761
PMCPMC10855893
OpenAlexW4391230107

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.