Evidence map›Paper›PMID 38338687›Full record

ReviewInternational journal of molecular sciences2024

Mucosal Immunity of Major Gastrointestinal Nematode Infections in Small Ruminants Can Be Harnessed to Develop New Prevention Strategies.

P G Ashani S Palkumbura, Thilini A N Mahakapuge, R R M K Kavindra Wijesundera, Viskam Wijewardana, Richard Thiga Kangethe, R P V Jayanthe Rajapakse

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Catalytically Active Recombinant Cysteine Proteases ofInternational journal of molecular sciences · 2025
    Article
  3. Occurrence of Internal Parasites and Anthelmintic Resistance in Goats.Animals : an open access journal from MDPI · 2025
    Article
  4. Article
  5. Survey ofTransboundary and emerging diseases · 2025
    Article
  6. Article
  7. Modern Strategies for Diagnosis and Treatment of Parasitic Diseases.International journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

P G Ashani S PalkumburaDepartment of Veterinary Pathobiology, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Kandy 20400, Sri Lanka.
Thilini A N MahakapugeDepartment of Veterinary Pathobiology, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Kandy 20400, Sri Lanka.
R R M K Kavindra WijesunderaDepartment of Veterinary Pathobiology, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Kandy 20400, Sri Lanka.
Viskam WijewardanaAnimal Production and Health Laboratory, Joint FAO/IAEA Centre of Nuclear Techniques in Food and Agriculture, International Atomic Energy Agency, 2444 Seibersdorf, Austria.
Richard Thiga KangetheAnimal Production and Health Laboratory, Joint FAO/IAEA Centre of Nuclear Techniques in Food and Agriculture, International Atomic Energy Agency, 2444 Seibersdorf, Austria.ORCID 0000-0002-2598-9324
R P V Jayanthe RajapakseDepartment of Veterinary Pathobiology, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Kandy 20400, Sri Lanka.
University of Peradeniya · LKInternational Atomic Energy Agency · AT

Funding

International Atomic Energy Agency TC SRL5046
6 · The paper itself

Abstract

Gastrointestinal parasitic nematode (GIN) infections are the cause of severe losses to farmers in countries where small ruminants such as sheep and goat are the mainstay of livestock holdings. There is a need to develop effective and easy-to-administer anti-parasite vaccines in areas where anthelmintic resistance is rapidly rising due to the inefficient use of drugs currently available. In this review, we describe the most prevalent and economically significant group of GIN infections that infect small ruminants and the immune responses that occur in the host during infection with an emphasis on mucosal immunity. Furthermore, we outline the different prevention strategies that exist with a focus on whole and purified native parasite antigens as vaccine candidates and their possible oral-nasal administration as a part of an integrated parasite control toolbox in areas where drug resistance is on the rise.

Indexed as

AnthelminticsCommunicable DiseasesGastrointestinal DiseasesNematodaNematode InfectionsSheep DiseasesAnimalsGoatsImmunity, MucosalRuminantsSheepAnthelminticshelminthirradiated parasitespurified parasite productsvaccinationwhole parasite

Identifiers

PMID38338687
PMCPMC10855138
OpenAlexW4391170305

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.