Evidence map›Paper›PMID 38338651›Full record

ArticleInternational journal of molecular sciences2024

Leucine Zipper Downregulated in Cancer-1 Interacts with Clathrin Adaptors to Control Epidermal Growth Factor Receptor (EGFR) Internalization and Gefitinib Response in EGFR-Mutated Non-Small Cell Lung Cancer.

Hsien-Neng Huang, Pin-Feng Hung, Yai-Ping Chen, Chia-Huei Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Recent advances in TAM mechanisms in lung diseases.Journal of translational medicine · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Hsien-Neng HuangDepartment of Pathology, National Taiwan University Hospital Hsin-Chu Branch, No. 25, Ln. 442, Section 1, Jingguo Road, North Dist., Hsinchu 300195, Taiwan.
Pin-Feng HungNational Institute of Cancer Research, National Health Research Institutes, No. 35, Keyan Road, Zhunan 350401, Taiwan.
Yai-Ping ChenNational Institute of Cancer Research, National Health Research Institutes, No. 35, Keyan Road, Zhunan 350401, Taiwan.
Chia-Huei LeeNational Institute of Cancer Research, National Health Research Institutes, No. 35, Keyan Road, Zhunan 350401, Taiwan.ORCID 0000-0002-8847-3288
National Health Research Institutes · TWNational Taiwan University · TW

Funding

Chang Gung Memorial Hospital, Keelung, Taiwan CMRPG2N0071National Health Research Institutes, Taiwan CA-112-PP-05National Health Research Institutes, Taiwan CA-112-SP-10National Taiwan University Hospital Hsin-Chu Branch, Taiwan NHRI-112-B03
6 · The paper itself

Abstract

The epidermal growth factor receptor (EGFR) is a common driver of non-small cell lung cancer (NSCLC). Clathrin-mediated internalization (CMI) sustains EGFR signaling. AXL is associated with resistance to EGFR-tyrosine kinase inhibitors (TKIs) in EGFR-mutated (EGFR

Indexed as

Antineoplastic AgentsCarcinoma, Non-Small-Cell LungLung NeoplasmsAdaptor Proteins, Vesicular TransportCell Line, TumorDrug Resistance, NeoplasmErbB ReceptorsGefitinibHumansLeucine ZippersMutationNuclear ProteinsProtein Kinase InhibitorsQuinazolinesTumor Suppressor ProteinsAdaptor Proteins, Vesicular TransportAntineoplastic AgentsEGFR protein, humanErbB ReceptorsGefitinibLDOC1 protein, humanNuclear ProteinsProtein Kinase InhibitorsQuinazolinesTumor Suppressor Proteinsclathrin adaptor proteinepidermal growth factor receptor (EGFR)gefitinibLeucine zipper downregulated in cancer-1 (LDOC1)non-small cell lung cancer (NSCLC)

Identifiers

PMID38338651
PMCPMC10855387
OpenAlexW4391141454

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.