Evidence map›Paper›PMID 38338332›Full record

ArticleMolecules (Basel, Switzerland)2024

HPLC and LC-MS/MS-Based Quantitative Characterization of Related Substances Associated with Sotalol Hydrochloride.

Pengyan Zhu, Xiaojing Shen, Xinting Wang, Xinlan Liu, Yingshuang Zhang, Ke Wang, Wenfen Gao, Xuanjun Wang, Wenjuan Yuan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pengyan ZhuCollege of Science, Yunnan Agricultural University, Kunming 650201, China.
Xiaojing ShenCollege of Science, Yunnan Agricultural University, Kunming 650201, China.
Xinting WangKey Laboratory of Puer Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming 650201, China.
Xinlan LiuKey Laboratory of Puer Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming 650201, China.
Yingshuang ZhangCollege of Science, Yunnan Agricultural University, Kunming 650201, China.
Ke WangCollege of Science, Yunnan Agricultural University, Kunming 650201, China.
Wenfen GaoYunnan Institute for Food and Drug Control, Kunming 650201, China.
Xuanjun WangYunnan Key Laboratory of Southern Medicinal Resource, School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming 650500, China.
Wenjuan YuanCollege of Science, Yunnan Agricultural University, Kunming 650201, China.

Funding

the National Natural Science Foundation of China 32060084
6 · The paper itself

Abstract

In total, three related substances (RS) associated with sotalol hydrochloride (STHCl) were herein identified with a novel gradient high-performance liquid chromatography (HPLC) protocol. Further characterization of these substances was then performed via liquid chromatography-mass spectroscopy (LC-MS/MS) and nuclear magnetic resonance (NMR) approaches. For these analyses, commercial STHCl samples were used for quantitative HPLC studies and the degradation of STHCl under acidic (1M HCl), alkaline (1M NaOH), oxidative (30% H

Indexed as

SotalolTandem Mass SpectrometryChromatography, High Pressure LiquidChromatography, LiquidDrug StabilityHydrogen PeroxideHydrolysisLiquid Chromatography-Mass SpectrometryOxidation-ReductionPhotolysisHydrogen PeroxideSotalolacute toxicitycharacterizationLC–MS/MSMTT analysisNMRrelated substancessotalol hydrochloride (STHCl)

Identifiers

PMID38338332
PMCPMC10856746

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.