ArticleDiagnostics (Basel, Switzerland)2024
The Role of New Morphological Parameters Provided by the BC 6800 Plus Analyzer in the Early Diagnosis of Sepsis.
Sara Sacchetti, Matteo Vidali, Teresa Esposito, Stefano Zorzi, Alessia Burgener, Lorenzo Ciccarello, Gianmaria Cammarota, Valentina Zanotti, Luca Giacomini, Mattia Bellan and 5 more
Open access · goldAbstract read
In one paragraphArticle in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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5 · Who and what moneyAuthors and funding
15 authors at 2 institutions in 1 country.
Sara SacchettiClinical Chemistry Laboratory, Department of Health Sciences, Università del Piemonte Orientale, Maggiore della Carità University Hospital, 28100 Novara, Italy.ORCID 0009-0001-3928-4173 Matteo VidaliClinical Pathology Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.ORCID 0000-0001-9991-7502 Teresa EspositoUnit of Anaesthesia and Intensive Care, Department of Translational Medicine, Università del Piemonte Orientale, Maggiore della Carità University Hospital, 28100 Novara, Italy.
Stefano ZorziUnit of Anaesthesia and Intensive Care, Department of Translational Medicine, Università del Piemonte Orientale, Maggiore della Carità University Hospital, 28100 Novara, Italy.ORCID 0009-0003-3051-9209 Alessia BurgenerUnit of Anaesthesia and Intensive Care, Department of Translational Medicine, Università del Piemonte Orientale, Maggiore della Carità University Hospital, 28100 Novara, Italy.
Lorenzo CiccarelloUnit of Anaesthesia and Intensive Care, Department of Translational Medicine, Università del Piemonte Orientale, Maggiore della Carità University Hospital, 28100 Novara, Italy.
Gianmaria CammarotaUnit of Anaesthesia and Intensive Care, Department of Translational Medicine, Università del Piemonte Orientale, Maggiore della Carità University Hospital, 28100 Novara, Italy.
Valentina ZanottiClinical Chemistry Laboratory, Department of Health Sciences, Università del Piemonte Orientale, Maggiore della Carità University Hospital, 28100 Novara, Italy.ORCID 0009-0006-1927-1566 Luca GiacominiClinical Chemistry Laboratory, Department of Health Sciences, Università del Piemonte Orientale, Maggiore della Carità University Hospital, 28100 Novara, Italy.
Mattia BellanDepartment of Translational Medicine, Division of Internal Medicine, Università del Piemonte Orientale, "Maggiore della Carità" University Hospital, 28100 Novara, Italy.ORCID 0000-0003-1488-8736 Mario PirisiDepartment of Translational Medicine, Division of Internal Medicine, Università del Piemonte Orientale, "Maggiore della Carità" University Hospital, 28100 Novara, Italy.ORCID 0000-0001-9740-0155 Ramon Simon LopezMedical Xpert Systems SA, Brunnenmattstrasse 6, 6317 Oberwil bei Zug, Switzerland.
Umberto DianzaniClinical Chemistry Laboratory, Department of Health Sciences, Università del Piemonte Orientale, Maggiore della Carità University Hospital, 28100 Novara, Italy.
Rosanna VaschettoUnit of Anaesthesia and Intensive Care, Department of Translational Medicine, Università del Piemonte Orientale, Maggiore della Carità University Hospital, 28100 Novara, Italy.ORCID 0000-0003-4625-4367 Roberta RollaClinical Chemistry Laboratory, Department of Health Sciences, Università del Piemonte Orientale, Maggiore della Carità University Hospital, 28100 Novara, Italy.ORCID 0000-0003-0805-8285 Università degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · IT
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
backgroundLate diagnosis of sepsis is associated with adverse consequences and high mortality rate. The aim of this study was to evaluate the diagnostic value of hematologic research parameters, that reflect the cell morphology of blood cells, available on the BC 6800 plus automated analyzer (Mindray) for the early detection of sepsis. MATERIALS AND
methodsA complete blood count (CBC) was performed by Mindray BC 6800 Plus Analyzer in 327 patients (223 with a confirmed diagnosis of sepsis following sepsis-3 criteria, 104 without sepsis), admitted at the Intensive Care Unit of the Novara's Hospital (Italy) and in 56 patients with localized infection.
resultsIn univariate logistic regression, age, Hb, RDW, MO#, NMR, NeuX, NeuY, NeuZ, LymX, MonX, MonY, MonZ were associated with sepsis (
conclusionsIn addition to already established biomarkers and basic CBC parameters, new morphological cell parameters can be a valuable aid in the early diagnosis of sepsis at no additional cost.
Indexed as
affordable health careearly diagnosisleukocyte parametersmorphological changesRed Cell Distribution Width (RDW)sepsis
Identifiers
PMID38337856
PMCPMC10855753
OpenAlexW4391556239
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