Evidence map›Paper›PMID 38337824›Full record

ArticleDiagnostics (Basel, Switzerland)2024

Time-Dependent Changes in Hematoma Expansion Rate after Supratentorial Intracerebral Hemorrhage and Its Relationship with Neurological Deterioration and Functional Outcome.

Gaby Abou Karam, Min-Chiun Chen, Dorin Zeevi, Bendix C Harms, Victor M Torres-Lopez, Cyprien A Rivier, Ajay Malhotra, Adam de Havenon, Guido J Falcone, Kevin N Sheth and 1 more

Abstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Advances in Cerebrovascular Imaging and Interventions.Diagnostics (Basel, Switzerland) · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Gaby Abou KaramDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT 06520, USA.ORCID 0009-0003-3540-7185
Min-Chiun ChenDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT 06520, USA.
Dorin ZeeviDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT 06520, USA.
Bendix C HarmsDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT 06520, USA.
Victor M Torres-LopezDepartment of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA.
Cyprien A RivierDepartment of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA.
Ajay MalhotraDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0001-9223-6640
Adam de HavenonDepartment of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA.
Guido J FalconeDepartment of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA.
Kevin N ShethDepartment of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA.
Seyedmehdi PayabvashDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0003-4628-0370

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Study Support Suite (YES3): Dashboard and Web Portal Software Supporting Research Workflow through integrated, customizable REDCap External ModulesP30AG021342 · NIA · YALE UNIVERSITY · PI Albert C Shaw · 2002 to 2026
$37.9M
Anticoagulation in ICH Survivors for Prevention and Recovery (ASPIRE)U01NS106513 · NINDS · YALE UNIVERSITY · PI Hooman Kamel, Kevin Navin Sheth · 2019 to 2026
$20.6M
CTP to predict Response to recanalization in Ischemic Stroke Project (CRISP)R01NS075209 · NINDS · STANFORD UNIVERSITY · PI LANSBERG, MAARTEN G · 2011 to 2023
$6.0M
Southern New England Partnership In Stroke Research, Innovation and Treatment (SPIRIT)U24NS107215 · NINDS · YALE UNIVERSITY · PI MARK Jay ALBERTS, Karen L Furie · 2018 to 2026
$3.0M
Blood Pressure Variability and Ischemic Stroke Outcome (BP-VISO)R01NS130189 · NINDS · YALE UNIVERSITY · PI Adam H. de Havenon · 2023 to 2026
$2.0M
CAPTIVA-MRIUG3NS130228 · NINDS · YALE UNIVERSITY · PI AMIN-HANJANI, SEPIDEH, CHATTERJEE, ARINDAM R. · 2023 to 2023
$1.9M
Improved glyburide therapy via acid- triggered release functional nanoparticles and therapeutic imagingR01NS110721 · NINDS · YALE UNIVERSITY · PI SHETH, KEVIN NAVIN, ZHOU, JIANGBING · 2019 to 2023
$1.9M
Yale Clinical Site: Investigations For Improved Neurological Treatments at Yale (INFINITY)U24NS107136 · NINDS · YALE UNIVERSITY · PI SHETH, KEVIN NAVIN, SPUDICH, SERENA S · 2018 to 2022
$1.7M
Yale site for Stroke Preclinical Assessment Network (SPAN) for Acute NeuroprotectionU01NS113445 · NINDS · YALE UNIVERSITY · PI SANSING, LAUREN H · 2019 to 2021
$1.2M
Treatment Targets for Inflamed Intracranial Atherosclerosis on Vessel Wall MRIK23NS105924 · NINDS · YALE UNIVERSITY · PI DE HAVENON, ADAM H. · 2019 to 2023
$988k
Radiomics Signatures and Patient Outcomes in Intracerebral HemorrhageK23NS118056 · NINDS · YALE UNIVERSITY · PI Seyedmehdi Payabvash · 2021 to 2026
$780k
Doris Duke Charitable Foundation 2020097NCATS NIH HHS UL1 TR001863NIA NIH HHS P30 AG021342NINDS NIH HHS K23 NS105924NINDS NIH HHS K23 NS118056NINDS NIH HHS K23NS118056NINDS NIH HHS R01 NS075209NINDS NIH HHS R01 NS110721NINDS NIH HHS R01 NS130189NINDS NIH HHS R03 NS112859NINDS NIH HHS U01 NS106513NINDS NIH HHS U01 NS113445NINDS NIH HHS U24 NS107136NINDS NIH HHS U24 NS107215NINDS NIH HHS UG3 NS130228
6 · The paper itself

Abstract

backgroundHematoma expansion (HE) following an intracerebral hemorrhage (ICH) is a modifiable risk factor and a treatment target. We examined the association of HE with neurological deterioration (ND), functional outcome, and mortality based on the time gap from onset to baseline CT.

methodsWe included 567 consecutive patients with supratentorial ICH and baseline head CT within 24 h of onset. ND was defined as a ≥4-point increase on the NIH stroke scale (NIHSS) or a ≥2-point drop on the Glasgow coma scale. Poor outcome was defined as a modified Rankin score of 4 to 6 at 3-month follow-up.

resultsThe rate of HE was higher among those scanned within 3 h (124/304, 40.8%) versus 3 to 24 h post-ICH onset (53/263, 20.2%) (

conclusionDespite decreasing rates over time after ICH onset, HE remains an independent predictor of ND, functional outcome, and mortality among those presenting >3 h after onset or with mild symptoms.

Indexed as

hematoma expansionhemorrhagic strokeintracerebral hemorrhageneurological deteriorationoutcome

Identifiers

PMID38337824
PMCPMC10855868

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.