ArticleDiagnostics (Basel, Switzerland)2024
Juvenile Primary Sjögren Syndrome in a 15-Year-Old Boy with Renal Involvement: A Case Report and Review of the Literature.
Article in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 3 citations in OpenAlex.
- Pediatric Sjögren's Disease: Literature Review and Diagnostic Challenges in an Uncommon Case.Diagnostics (Basel, Switzerland) · 2026Article
- Elevated IL-8 and abnormal lymphocytes in pediatric primary Sjögren's syndrome: a single-center study.European journal of medical research · 2026Article
- Case Report: Autoimmune-associated tubulointerstitial nephritis with predominant Sjögren features in a child presenting with recurrent sterile pyuria.Frontiers in pediatrics · 2026Article
- Childhood-onset primary Sjögren's Syndrome presenting as nephrotic syndrome: a case report and literature review.BMC pediatrics · 2025Review
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Juvenile primary Sjögren syndrome (pSS) with renal involvement is extremely rare, reported approximately in 50 children, predominantly girls. Here, we present the first reported case of a male child with juvenile pSS with ocular surface disease (previously keratoconjunctivitis sicca), submandibular salivary gland involvement, and tubulointerstitial nephritis. First, two symptoms were clinically apparent at presentation. We illustrate here that kidney involvement in pSS should be actively looked for, as juvenile pSS may be associated with asymptomatic renal involvement. Immunophenotyping of peripheral blood cells using multicolor flow cytometry revealed at the time of diagnosis changes in both adaptive (T memory cells and B memory cells), and innate immunity (an increased activation of natural killer cells, as well as monocytes and neutrophils, and an increased representation of intermediate monocytes). Our case report points to the importance of kidney examination, early diagnosis and therapy in juvenile pSS, as well as highlights international collaboration to obtain more data for this rare disease.
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Registered trials
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