Evidence map›Paper›PMID 38337658›Full record

Trial reportNutrients2024

A 14-Day Double-Blind, Randomized, Controlled Crossover Intervention Study with Anti-Bacterial Benzyl Isothiocyanate from Nasturtium (

Simon P Pfäffle, Corinna Herz, Eva Brombacher, Michele Proietti, Michael Gigl, Christoph K Hofstetter, Verena K Mittermeier-Kleßinger, Sophie Claßen, Hoai T T Tran, Dhairya Rajguru and 4 more

Erratum issuedOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Simon P PfäffleMolecular Preventive Medicine, University Medical Center and Faculty of Medicine, University of Freiburg, Engesserstrasse 4, D-79108 Freiburg, Germany.ORCID 0009-0007-4492-4298
Corinna HerzMolecular Preventive Medicine, University Medical Center and Faculty of Medicine, University of Freiburg, Engesserstrasse 4, D-79108 Freiburg, Germany.
Eva BrombacherInstitute of Medical Biometry and Statistics, University Medical Center and Faculty of Medicine, University of Freiburg, Stefan-Meier-Str. 26, D-79104 Freiburg, Germany.
Michele ProiettiCenter for Chronic Immunodeficiency (CCI), Microbiome Core Facility, Breisacher Strasse 115, D-79106 Freiburg, Germany.
Michael GiglChair of Food Chemistry and Molecular Sensory Science, TUM School of Life Sciences, Technical University of Munich, Lise-Meitner-Strasse 34, D-85354 Freising, Germany.ORCID 0000-0002-5617-9236
Christoph K HofstetterChair of Food Chemistry and Molecular Sensory Science, TUM School of Life Sciences, Technical University of Munich, Lise-Meitner-Strasse 34, D-85354 Freising, Germany.
Verena K Mittermeier-KleßingerChair of Food Chemistry and Molecular Sensory Science, TUM School of Life Sciences, Technical University of Munich, Lise-Meitner-Strasse 34, D-85354 Freising, Germany.
Sophie ClaßenMolecular Preventive Medicine, University Medical Center and Faculty of Medicine, University of Freiburg, Engesserstrasse 4, D-79108 Freiburg, Germany.
Hoai T T TranMolecular Preventive Medicine, University Medical Center and Faculty of Medicine, University of Freiburg, Engesserstrasse 4, D-79108 Freiburg, Germany.ORCID 0000-0001-5736-898X
Dhairya RajguruInstitute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg, D-79104 Freiburg, Germany
Corinna DawidChair of Food Chemistry and Molecular Sensory Science, TUM School of Life Sciences, Technical University of Munich, Lise-Meitner-Strasse 34, D-85354 Freising, Germany.ORCID 0000-0001-5342-2600
Clemens KreutzInstitute of Medical Biometry and Statistics, University Medical Center and Faculty of Medicine, University of Freiburg, Stefan-Meier-Str. 26, D-79104 Freiburg, Germany.ORCID 0000-0002-8796-5766
Stefan GüntherInstitute of Pharmaceutical Sciences, Faculty of Chemistry and Pharmacy, University of Freiburg, Hermann-Herder-Strasse 9, D-79104 Freiburg, Germany.ORCID 0000-0003-3744-189X
Evelyn LamyMolecular Preventive Medicine, University Medical Center and Faculty of Medicine, University of Freiburg, Engesserstrasse 4, D-79108 Freiburg, Germany.ORCID 0000-0002-5620-1595
University of Freiburg · DETechnical University of Munich · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite substantial heterogeneity of studies, there is evidence that antibiotics commonly used in primary care influence the composition of the gastrointestinal microbiota in terms of changing their composition and/or diversity. Benzyl isothiocyanate (BITC) from the food and medicinal plant nasturtium (

Indexed as

Gastrointestinal MicrobiomeNasturtiumTropaeolumBacteriaEscherichia coliFemaleHumansIsothiocyanatesMetabolomebenzyl isothiocyanateIsothiocyanatesantimicrobialBITCEscherichia coligut microbiomehuman beta defensin 1metabolomenasturtium

Identifiers

PMID38337658
PMCPMC10857499
OpenAlexW4391263333

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.