Evidence map›Paper›PMID 38337589›Full record

ReviewJournal of clinical medicine2024

Altered Autonomic Function in Metabolic Syndrome: Interactive Effects of Multiple Components.

Joseph Mannozzi, Louis Massoud, Jon Stavres, Mohamed-Hussein Al-Hassan, Donal S O'Leary

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Joseph MannozziDepartment of Physiology, Wayne State University School of Medicine, Detroit, MI 48001, USA.ORCID 0000-0002-0815-6355
Louis MassoudDepartment of Physiology, Wayne State University School of Medicine, Detroit, MI 48001, USA.
Jon StavresSchool of Kinesiology and Nutrition, University of Southern Mississippi, Hattiesburg, MS 39406, USA.ORCID 0000-0003-0564-7252
Mohamed-Hussein Al-HassanDepartment of Physiology, Wayne State University School of Medicine, Detroit, MI 48001, USA.
Donal S O'LearyDepartment of Physiology, Wayne State University School of Medicine, Detroit, MI 48001, USA.
Wayne State University · USUniversity of Southern Mississippi · US

Funding

BLOOD PRESSURE CONTROL DURING EXERCISE IN HEART FAILURER01HL055473 · NHLBI · WAYNE STATE UNIVERSITY · PI O'LEARY, DONAL S · 1996 to 2024
$9.8M
Mechanisms Mediating Enhanced Sympatho-Activation During Exercise in HypertensionR01HL126706 · NHLBI · WAYNE STATE UNIVERSITY · PI O'LEARY, DONAL S · 2016 to 2019
$2.2M
Detroit Cardiovascular Training ProgramT32HL120822 · NHLBI · WAYNE STATE UNIVERSITY · PI LEVY, PHILLIP DAVID · 2014 to 2023
$1.8M
National Heart Lung and Blood Institute 120822National Heart Lung and Blood Institute 126706National Heart Lung and Blood Institute 55473NHLBI NIH HHS R01 HL055473NHLBI NIH HHS R01 HL126706NHLBI NIH HHS T32 HL120822
6 · The paper itself

Abstract

Metabolic syndrome (MetS) describes a set of disorders that collectively influence cardiovascular health, and includes hypertension, obesity, insulin resistance, diabetes, and dyslipidemia. All these components (hypertension, obesity, dyslipidemia, and prediabetes/diabetes) have been shown to modify autonomic function. The major autonomic dysfunction that has been documented with each of these components is in the control of sympathetic outflow to the heart and periphery at rest and during exercise through modulation of the arterial baroreflex and the muscle metaboreflex. Many studies have described MetS components in singularity or in combination with the other major components of metabolic syndrome. However, many studies lack the capability to study all the factors of metabolic syndrome in one model or have not focused on studying the effects of how each component as it arises influences overall autonomic function. The goal of this review is to describe the current understanding of major aspects of metabolic syndrome that most likely contribute to the consequent/associated autonomic alterations during exercise and discuss their effects, as well as bring light to alternative mechanisms of study.

Indexed as

autonomic functionbaroreflexexercisehypertensionmetaboreflexMetSobesity

Identifiers

PMID38337589
PMCPMC10856260
OpenAlexW4391578334

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.