Evidence map›Paper›PMID 38337569›Full record

ArticleJournal of clinical medicine2024

Dopamine Synthesis in the Nigrostriatal Dopaminergic System in Patients at Risk of Developing Parkinson's Disease at the Prodromal Stage.

Victor Blokhin, Ekaterina N Pavlova, Elena A Katunina, Marina R Nodel, Galina V Kataeva, Elina R Moskalets, Tatiana S Pronina, Michael V Ugrumov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Gut Microbiome as a Source of Probiotic Drugs for Parkinson's Disease.International journal of molecular sciences · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Victor BlokhinLaboratory of Neural and Neuroendocrine Regulations, Koltzov Institute of Developmental Biology of Russian Academy of Sciences, Moscow 119334, Russia.ORCID 0000-0001-9074-7279
Ekaterina N PavlovaLaboratory of Neural and Neuroendocrine Regulations, Koltzov Institute of Developmental Biology of Russian Academy of Sciences, Moscow 119334, Russia.
Elena A KatuninaFederal Center of Brain Research and Neurotechnologies of the Russian Federal Medical and Biological Agency, Moscow 117513, Russia.
Marina R NodelDepartment of Nervous Diseases and Neurosurgery, Sechenov First Moscow State Medical University (Sechenov University), Moscow 119435, Russia.
Galina V KataevaFederal State Budget Institution Granov Russian Research Center of Radiology and Surgical Technologies Ministry of Health of the Russian Federation (RRCRST) 70, Leningradskaya Street, Pesochny, St. Petersburg 197758, Russia.
Elina R MoskaletsEuropean Medical Center, Moscow 129090, Russia.ORCID 0000-0002-0164-2422
Tatiana S ProninaLaboratory of Neural and Neuroendocrine Regulations, Koltzov Institute of Developmental Biology of Russian Academy of Sciences, Moscow 119334, Russia.
Michael V UgrumovLaboratory of Neural and Neuroendocrine Regulations, Koltzov Institute of Developmental Biology of Russian Academy of Sciences, Moscow 119334, Russia.
Koltzov Institute of Developmental Biology · RUMinistry of Health of the Russian Federation · RUPirogov Russian National Research Medical University · RUSechenov University · RU

Funding

Ministry of Science and Higher Education of the Russian Federation grant agreement No 075-15-2020-795, state contract No 13.1902.21.0027 of 29.09.2020, unique project ID: RF-190220X0027
6 · The paper itself

Abstract

Parkinson's disease (PD) is diagnosed by the onset of motor symptoms and treated long after its onset. Therefore, the development of the early diagnosis of PD is a priority for neurology. Advanced methodologies for this include (1) searching for patients at risk of developing prodromal PD based on premotor symptoms; (2) searching for changes in the body fluids in these patients as diagnostic biomarkers; (3) verifying the diagnosis of prodromal PD and diagnostic-value biomarkers using positron emission tomography (PET); (4) anticipating the development of motor symptoms. According to our data, the majority of patients (

Indexed as

18F-DOPAearly diagnosisnigrostriatal dopaminergic systemParkinson’s diseasepatientspositron emission tomographyprodromal

Identifiers

PMID38337569
PMCPMC10856030
OpenAlexW4391486481

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.