Evidence map›Paper›PMID 38337384›Full record

ArticleJournal of clinical medicine2024

Headache Attributed to Refractive Error: Improvement after Topography-Guided Photorefractive Keratectomy with Corneal Cross-Linking in Patients with Keratoconus.

Nigel Terk-Howe Khoo, Barbara Burgos-Blasco, Angelique Antoniou, Bronwyn Jenkins, Clare L Fraser, Gregory Moloney

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Living Well with Keratoconus: Implications for Person-Centred Eye Care.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Nigel Terk-Howe KhooSave Sight Institute, Faculty of Health and Medicine, The University of Sydney, Sydney, NSW 2050, Australia.
Barbara Burgos-BlascoOphthalmology Department, University of British Columbia, Vancouver, BC V5Z 1J9, Canada.ORCID 0000-0003-2178-6164
Angelique AntoniouNarellan Eye Specialists, Narellan, NSW 2567, Australia.
Bronwyn JenkinsRoyal North Shore Hospital, Sydney, NSW 2065, Australia.
Clare L FraserSave Sight Institute, Faculty of Health and Medicine, The University of Sydney, Sydney, NSW 2050, Australia.ORCID 0000-0002-0379-7743
Gregory MoloneyDiscipline of Ophthalmology, Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia.
The University of Sydney · AURoyal North Shore Hospital · AUUniversity of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate if topography-guided photorefractive keratectomy (TGPRK) alleviates headache, particularly headache attributed to refractive errors (HARE) in keratoconus.

methodsPatients diagnosed with keratoconus undergoing TGPRK for refractive correction were included. Best spectacle corrected visual acuity (BSCVA) using the logMAR scale and refractive error were measured. Patients answered a questionnaire exploring headaches, characteristics, treatment, and the Headache Impact Test (HIT-6) before and 6 months after the surgery.

results40 patients were included. Preoperatively, 24 patients (60%) met criteria for headaches: five for migraine, 14 for HARE, and five for tension-type headache (TTH). Patients with headaches preoperatively were more likely to require bilateral TGPRK, and the mean sphere and cylindrical power were higher. Postoperatively, 15 out of the 24 patients of the headache group experienced complete resolution of headaches, and only nine patients met diagnostic criteria for headaches: two for migraine, six for HARE, and one for TTH. The number of headaches reduced from 4.4 ± 2.4 to 0.5 ± 0.7 days/week (

conclusionsSurgical correction of irregular astigmatism in patients with keratoconus can alleviate or resolve headaches in a large proportion of patients, resulting in an improvement in their quality of life. Physicians should consider keratoconus in patients fitting criteria for HARE not alleviated by spectacle correction and suboptimal vision in glasses.

Indexed as

corneal cross-linkingheadachekeratoconusPRKrefractive errortopography guided photorefractive keratectomy

Identifiers

PMID38337384
PMCPMC10856040
OpenAlexW4391221225

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.