Evidence map›Paper›PMID 38337316›Full record

ArticlePolymers2024

Nanostructured Poly-l-lactide and Polyglycerol Adipate Carriers for the Encapsulation of Usnic Acid: A Promising Approach for Hepatoprotection.

Benedetta Brugnoli, Greta Perna, Sara Alfano, Antonella Piozzi, Luciano Galantini, Eleni Axioti, Vincenzo Taresco, Alessia Mariano, Anna Scotto d'Abusco, Stefano Vecchio Ciprioti and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Benedetta BrugnoliDepartment of Chemistry, Sapienza University of Rome, P.le A. Moro, 00185 Rome, Italy.ORCID 0000-0002-9419-2829
Greta PernaDepartment of Chemistry, Sapienza University of Rome, P.le A. Moro, 00185 Rome, Italy.
Sara AlfanoDepartment of Chemistry, Sapienza University of Rome, P.le A. Moro, 00185 Rome, Italy.ORCID 0000-0002-8460-800X
Antonella PiozziDepartment of Chemistry, Sapienza University of Rome, P.le A. Moro, 00185 Rome, Italy.ORCID 0000-0002-4792-0520
Luciano GalantiniDepartment of Chemistry, Sapienza University of Rome, P.le A. Moro, 00185 Rome, Italy.ORCID 0000-0001-5484-2658
Eleni AxiotiSchool of Chemistry, University of Nottingham, Nottingham NG7 2RD, UK.ORCID 0009-0006-6751-557X
Vincenzo TarescoSchool of Chemistry, University of Nottingham, Nottingham NG7 2RD, UK.ORCID 0000-0003-4476-8233
Alessia MarianoDepartment of Biochemical Sciences, Sapienza University of Rome, P.le A. Moro, 5, 00185 Rome, Italy.ORCID 0000-0002-9569-8952
Anna Scotto d'AbuscoDepartment of Biochemical Sciences, Sapienza University of Rome, P.le A. Moro, 5, 00185 Rome, Italy.ORCID 0000-0002-3323-6015
Stefano Vecchio CipriotiDepartment of Basic and Applied Science for Engineering, Sapienza University of Rome, Via del Castro Laurenziano 7, 00161 Rome, Italy.ORCID 0000-0002-7864-4266
Iolanda FrancoliniDepartment of Chemistry, Sapienza University of Rome, P.le A. Moro, 00185 Rome, Italy.ORCID 0000-0002-0180-2334

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study investigates the utilization of nanoparticles based on poly-l-lactide (PLLA) and polyglycerol adipate (PGA), alone and blended, for the encapsulation of usnic acid (UA), a potent natural compound with various therapeutic properties including antimicrobial and anticancer activities. The development of these carriers offers an innovative approach to overcome the challenges associated with usnic acid's limited aqueous solubility, bioavailability, and hepatotoxicity. The nanosystems were characterized according to their physicochemical properties (among others, size, zeta potential, thermal properties), apparent aqueous solubility, and in vitro cytotoxicity. Interestingly, the nanocarrier obtained with the PLLA-PGA 50/50 weight ratio blend showed both the lowest size and the highest UA apparent solubility as well as the ability to decrease UA cytotoxicity towards human hepatocytes (HepG2 cells). This research opens new avenues for the effective utilization of these highly degradable and biocompatible PLLA-PGA blends as nanocarriers for reducing the cytotoxicity of usnic acid.

Indexed as

drug deliverydrug hepatoprotectionpolyglycerol adipatepoly-l-lactidepolymer nanoparticlesusnic acid

Identifiers

PMID38337316
PMCPMC10857334

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.