ReviewPolymers2024
Poly(methyl methacrylate) in Orthopedics: Strategies, Challenges, and Prospects in Bone Tissue Engineering.
Review in Polymers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Presentations, management strategies, and outcomes of intracardiac cement embolism following spinal vertebral augmentation: a systematic review of case reports.Journal of orthopaedic surgery and research · 2025Pooled it
- Review
- Applications of DNA Hydrogels in Osteoporotic Bone Defects.Journal of functional biomaterials · 2026Review
- Antibiotic-Releasing Porous Shell Cements.Antibiotics (Basel, Switzerland) · 2026Article
- Engineering Smart Scaffolds for Osteomyelitis: Integrating Nanotechnology, Drug Delivery, and Tissue Regeneration-A Narrative Review.Journal of functional biomaterials · 2026Review
- Comparison of the Efficacy and Prognosis of Different Treatment Strategies for Spinal Tuberculosis Patients Undergoing Vertebral Augmentation Surgery by Mistake.Orthopaedic surgery · 2026Article
- Article
- Clinical outcomes of cement gun-assisted intramedullary nailing for femoral bone metastases: a retrospective case series.BMC musculoskeletal disorders · 2026Article
- A Facile and Versatile Technique for Creating Antifibrotic Coatings on Biomedical Implants.bioRxiv : the preprint server for biology · 2026Article
- Bioinspired and living multiscale composites for regenerative medicine in the treatment of surgical site infections.Journal of nanobiotechnology · 2026Review
- Photopolymerizable Imidazolium Methacrylate Networks for Controlled Dexamethasone Release: Potential Application in Uveitis Therapy.ACS omega · 2026Article
- Multifunctional MoS₂-PMMA bone cement with enhanced strength and antibacterial activity to overcome limitations of conventional materials in orthopedic surgery.BMC musculoskeletal disorders · 2026Article
- Engineering a Bioactive PMMA-Silica Hybrid Scaffold for Enhanced Bone Regeneration.ACS applied bio materials · 2026Article
- PMMA-augmentation of the spinous process as an enhancing-protective measure against bone failure in "through the spinous process-vertebropexy".North American Spine Society journal · 2026Article
- Robust adhesion between solid-state hydroxyapatite and bone tissue through surface demineralization.Bioactive materials · 2026Article
- Calcium Phosphate-Poly(methyl methacrylate) Composite Layers Synthetized in Radio-Frequency Magnetron Sputtering Discharge.Polymers · 2026Article
- Novel Bioresorbable Bone Wax for Potentiated Hemostasis and Osteogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Synergistic integration of biomaterials in orthopedic implantation for infection preventing and tissue engineering.Regenerative biomaterials · 2026Review
- Human hair keratin modification enhances the biocompatibility, bioactivity and osteogenic property of BCP/PMMA bone cement.Regenerative biomaterials · 2026Article
- Rapid Detection of Tetracycline Residues in Milk Using Colorimetric Sensor Based on Polymethylmethacrylate (PMMA) and Polystyrene (PS) Polymers.Journal of analytical methods in chemistry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Poly(methyl methacrylate) (PMMA) is widely used in orthopedic applications, including bone cement in total joint replacement surgery, bone fillers, and bone substitutes due to its affordability, biocompatibility, and processability. However, the bone regeneration efficiency of PMMA is limited because of its lack of bioactivity, poor osseointegration, and non-degradability. The use of bone cement also has disadvantages such as methyl methacrylate (MMA) release and high exothermic temperature during the polymerization of PMMA, which can cause thermal necrosis. To address these problems, various strategies have been adopted, such as surface modification techniques and the incorporation of various bioactive agents and biopolymers into PMMA. In this review, the physicochemical properties and synthesis methods of PMMA are discussed, with a special focus on the utilization of various PMMA composites in bone tissue engineering. Additionally, the challenges involved in incorporating PMMA into regenerative medicine are discussed with suitable research findings with the intention of providing insightful advice to support its successful clinical applications.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.