ArticleEuropean radiology2024
Deep medullary vein damage correlates with small vessel disease in small vessel occlusion acute ischemic stroke.
Article in European radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Deep Medullary Vein Asymmetry and Clinical Outcomes in Patients with Ischemic Stroke and Successful Endovascular Treatment.Journal of clinical medicine · 2026Article
- Association between cerebrovascular imaging markers and glymphatic function in a large-scale cognitively normal population.Neuroradiology · 2026Article
- The value of multiphase CT angiography in predicting hemorrhagic transformation after endovascular treatment: the arterial collaterals and venous drainage.Quantitative imaging in medicine and surgery · 2026Article
- Deep medullar veins: predictors of clinical progression in Alzheimer's disease.Quantitative imaging in medicine and surgery · 2026Article
- MRI Evaluation of Glymphatic Dysfunction in Cerebral Small Vessel Disease: Hypertensive vs. Normotensive Patients.The European journal of neuroscience · 2025Article
- Prominence of deep medullary veins associated with the risk of stroke in unilateral chronic internal carotid artery occlusion patients.Neuroradiology · 2025Article
- Deep Medullary Vein Integrity and Relationships with Small Vessel Disease and Interstitial Diffusivity Measures in Patients with a Recent Small Subcortical Infarct.AJNR. American journal of neuroradiology · 2025Article
- Automatic segmentation and diameter measurement of deep medullary veins.Magnetic resonance in medicine · 2025Article
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22 authors.
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Abstract
objectivesWe aim to investigate whether cerebral small vessel disease (cSVD) imaging markers correlate with deep medullary vein (DMV) damage in small vessel occlusion acute ischemic stroke (SVO-AIS) patients.
methodsThe DMV was divided into six segments according to the regional anatomy. The total DMV score (0-18) was calculated based on segmental continuity and visibility. The damage of DMV was grouped according to the quartiles of the total DMV score. Neuroimaging biomarkers of cSVD including white matter hyperintensity (WMH), cerebral microbleed (CMB), perivascular space (PVS), and lacune were identified. The cSVD score were further analyzed.
resultsWe included 229 SVO-AIS patients, the mean age was 63.7 ± 23.1 years, the median NIHSS score was 3 (IQR, 2-6). In the severe DMV burden group (the 4th quartile), the NIHSS score grade (6 (3-9)) was significantly higher than other groups (p < 0.01). The grade scores for basal ganglia PVS (BG-PVS) were positively correlated with the degree of DMV (R = 0.67, p < 0.01), rather than centrum semivole PVS (CS-PVS) (R = 0.17, p = 0.1). In multivariate analysis, high CMB burden (adjusted odds ratio [aOR], 25.38; 95% confidence interval [CI], 1.87-345.23) was associated with severe DMV scores. In addition, BG-PVS was related to severe DMV burden in a dose-dependent manner: when BG-PVS score was 3 and 4, the aORs of severe DMV burden were 18.5 and 12.19, respectively.
conclusionThe DMV impairment was associated with the severity of cSVD, which suggests that DMV burden may be used for risk stratification in SVO-AIS patients. CLINICAL RELEVANCE STATEMENT: The DMV damage score, based on the association between small vessel disease and the deep medullary veins impairment, is a potential new imaging biomarker for the prognosis of small vessel occlusion acute ischemic stroke, with clinical management implications. KEY POINTS: • The damage to the deep medullary vein may be one mechanism of cerebral small vessel disease. • Severe burden of the basal ganglia perivascular space and cerebral microbleed is closely associated with significant impairment to the deep medullary vein. • The deep medullary vein damage score may reflect a risk of added vascular damage in small vessel occlusion acute ischemic stroke patients.
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