ArticleNature communications2024
Amyloid-β aggregates activate peripheral monocytes in mild cognitive impairment.
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Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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0cells of the map it votes in
19citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
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Who cites it
19 citing papers in PubMed, 23 citations in OpenAlex.
- Passive amyloid-β immunotherapy in Alzheimer's disease: a multicellular clearance system beyond plaque removal.Molecular neurodegeneration · 2026Review
- Efficacy of Aerobic Versus Non-aerobic Exercise in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis Based on RCTs.Annals of Indian Academy of Neurology · 2026Article
- Article
- Review
- Immune dysfunction in Alzheimer disease.Nature reviews. Neuroscience · 2026Review
- Review
- Blood-brain barrier dysfunction and peripheral immune activation in Alzheimer's disease: an inflammation-centered review.Frontiers in immunology · 2026Review
- Immunosenescence in aging and neurodegenerative diseases: evidence, key hallmarks, and therapeutic implications.Translational neurodegeneration · 2025Review
- Monocyte inflammation and resilience to Alzheimer's disease: novel genetic risk genes identified by transcriptome-wide association study.Translational psychiatry · 2025Article
- Proteomic signatures and mitochondrial dysfunctions in peripheral T cells reveal novel ınsights into Alzheimer's disease.Scientific reports · 2025Article
- The immune response within Alzheimer's disease: from the lense of peripheral monocyte-derived macrophages.Journal of neuroimmunology · 2025Review
- Ultrasonic disruption of circulating amyloid β aggregates via phase-change peptide nanoemulsions.Biomaterials · 2025Article
- Large soluble CD18 complexes with exclusive ICAM-1-binding properties are shed during immune cell migration in inflammation.Journal of translational autoimmunity · 2025Article
- Early transcriptional and cellular abnormalities in choroid plexus of a mouse model of Alzheimer's disease.Molecular neurodegeneration · 2025Article
- Article
- Peripheral proteinopathy in neurodegenerative diseases.Translational neurodegeneration · 2025Review
- Osteoclast-like multinucleated giant cells reinforce polycaprolactone grafts.Frontiers in immunology · 2025Article
- Mapping microglial mechanisms in Alzheimer's disease: a comprehensive analysis.Experimental biology and medicine (Maywood, N.J.) · 2025Article
- Acute transcutaneous auricular vagus nerve stimulation modulates presynaptic SV2A density in healthy rat brain: An in vivo microPET study.Psychophysiology · 2025Article
Corrections and comments
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Authors and funding
22 authors at 6 institutions in 4 countries.
Kristian Juul-MadsenDepartment of Biomedicine, Aarhus University, The Skou Building, Høegh-Guldbergs Gade 10, DK-8000, Aarhus C, Denmark.ORCID 0000-0002-5309-5221
Peter ParboDepartment of Nuclear Medicine, Odense University Hospital, J. B. Winsløws Vej 4, DK-5000, Odense C, Denmark.ORCID 0000-0002-5792-1607
Rola IsmailDepartment of Nuclear medicine and PET, Vejle Hospital, Beriderbakken 4, DK-7100, Vejle, Denmark.
Peter L OvesenMax-Delbrueck-Center for Molecular Medicine, Robert-Rössle-Str. 10, 13125, Berlin, Germany.
Vanessa SchmidtMax-Delbrueck-Center for Molecular Medicine, Robert-Rössle-Str. 10, 13125, Berlin, Germany.
Lasse S MadsenDepartment of Nuclear Medicine & PET Centre, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, DK-8200, Aarhus N, Denmark.ORCID 0000-0002-5721-9885
Jacob ThyrstedDepartment of Biomedicine, Aarhus University, The Skou Building, Høegh-Guldbergs Gade 10, DK-8000, Aarhus C, Denmark.
Sarah GierlDepartment of Biomedicine, Aarhus University, The Skou Building, Høegh-Guldbergs Gade 10, DK-8000, Aarhus C, Denmark.
Mihaela BreumDepartment of Biomedicine, Aarhus University, The Skou Building, Høegh-Guldbergs Gade 10, DK-8000, Aarhus C, Denmark.
Agnete LarsenDepartment of Biomedicine, Aarhus University, The Skou Building, Høegh-Guldbergs Gade 10, DK-8000, Aarhus C, Denmark.
Morten N AndersenDepartment of Biomedicine, Aarhus University, The Skou Building, Høegh-Guldbergs Gade 10, DK-8000, Aarhus C, Denmark.ORCID 0000-0003-0820-7789
Marina Romero-RamosDepartment of Biomedicine, Aarhus University, The Skou Building, Høegh-Guldbergs Gade 10, DK-8000, Aarhus C, Denmark.ORCID 0000-0003-0970-578X
Christian K HolmDepartment of Biomedicine, Aarhus University, The Skou Building, Høegh-Guldbergs Gade 10, DK-8000, Aarhus C, Denmark.ORCID 0000-0002-2655-3362
Gregers R AndersenDepartment of Molecular Biology and Genetics, Aarhus University, Universitetsbyen 81, DK-8000, Aarhus C, Denmark.ORCID 0000-0001-6292-3319
Huaying ZhaoLaboratory of Dynamics and Macromolecular Assembly, National Institute of Biomedical Imaging and Bioengineering, Building 31, 9000 Rockville Pike, Bethesda, MD, 20892, USA.ORCID 0000-0002-8827-6639
Peter SchuckLaboratory of Dynamics and Macromolecular Assembly, National Institute of Biomedical Imaging and Bioengineering, Building 31, 9000 Rockville Pike, Bethesda, MD, 20892, USA.ORCID 0000-0002-8859-6966
Jens V NygaardDepartment of Biological and Chemical Engineering, Aarhus University, Gustav Wieds vej 10 D, DK-8200, Aarhus C, Denmark.ORCID 0000-0003-2442-1443
Duncan S SutherlandInterdisiciplinary Nanoscience Center, Aarhus University, The iNANO House, Gustav Wieds Vej 14, DK-8200, Aarhus C, Denmark.ORCID 0000-0002-5045-9915
Simon F EskildsenDepartment of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 11, DK-8200, Aarhus N, Denmark.ORCID 0000-0003-4242-9158
Thomas E WillnowDepartment of Biomedicine, Aarhus University, The Skou Building, Høegh-Guldbergs Gade 10, DK-8000, Aarhus C, Denmark.
David J BrooksDepartment of Nuclear Medicine & PET Centre, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, DK-8200, Aarhus N, Denmark.
Thomas Vorup-JensenDepartment of Biomedicine, Aarhus University, The Skou Building, Høegh-Guldbergs Gade 10, DK-8000, Aarhus C, Denmark. vorup-jensen@biomed.au.dk.ORCID 0000-0002-4140-6563
Aarhus University · DKMax Delbrück Center · DENational Institute of Biomedical Imaging and Bioengineering · USHammersmith Hospital · GBOdense University Hospital · DKVejle Sygehus · DK
Funding
Dynamics of Protein Assemblies by Analytical UltracentrifugationZIAEB000051 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI SCHUCK, PETER · 2009 to 2025
$7.9MAarhus Universitets Forskningsfond (Aarhus University Research Foundation) AUFF-E-2015-FLS-9-6Aarhus Universitets Forskningsfond (Aarhus University Research Foundation) AU IDEAS 2013Danmarks Grundforskningsfond (Danish National Research Foundation) DNRF135Det Frie Forskningsråd (Danish Council for Independent Research) 2030-00002BDet Frie Forskningsråd (Danish Council for Independent Research) 3101-00104BDet Frie Forskningsråd (Danish Council for Independent Research) 4004-00305EC | EU Framework Programme for Research and Innovation H2020 | H2020 European Institute of Innovation and Technology (H2020 The European Institute of Innovation and Technology) 820636Lundbeckfonden (Lundbeck Foundation) R380-2021-1326Novo Nordisk Fonden (Novo Nordisk Foundation) NNF19OC0058516Novo Nordisk Fonden (Novo Nordisk Foundation) NNF21OC0071574
Abstract
The peripheral immune system is important in neurodegenerative diseases, both in protecting and inflaming the brain, but the underlying mechanisms remain elusive. Alzheimer's Disease is commonly preceded by a prodromal period. Here, we report the presence of large Aβ aggregates in plasma from patients with mild cognitive impairment (n = 38). The aggregates are associated with low level Alzheimer's Disease-like brain pathology as observed by
Indexed as
Alzheimer DiseaseAmyloid beta-PeptidesCognitive DysfunctionHumansIntegrin alphaXbeta2MonocytesAmyloid beta-PeptidesIntegrin alphaXbeta2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.