Evidence map›Paper›PMID 38336906›Full record

ArticleScientific reports2024

Drosophila expressing mutant human KCNT1 transgenes make an effective tool for targeted drug screening in a whole animal model of KCNT1-epilepsy.

Rashid Hussain, Chiao Xin Lim, Zeeshan Shaukat, Anowarul Islam, Emily A Caseley, Jonathan D Lippiat, Grigori Y Rychkov, Michael G Ricos, Leanne M Dibbens

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. A transporter's doom or destiny:Frontiers in molecular neuroscience · 2024
    Review
  6. The fruit flyFrontiers in pharmacology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Rashid HussainEpilepsy Research Group, Clinical and Health Sciences, Australian Centre for Precision Health, University of South Australia, Adelaide, SA, 5000, Australia.
Chiao Xin LimEpilepsy Research Group, Clinical and Health Sciences, Australian Centre for Precision Health, University of South Australia, Adelaide, SA, 5000, Australia.
Zeeshan ShaukatEpilepsy Research Group, Clinical and Health Sciences, Australian Centre for Precision Health, University of South Australia, Adelaide, SA, 5000, Australia.
Anowarul IslamEpilepsy Research Group, Clinical and Health Sciences, Australian Centre for Precision Health, University of South Australia, Adelaide, SA, 5000, Australia.
Emily A CaseleySchool of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK.ORCID 0000-0001-7591-143X
Jonathan D LippiatSchool of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK.ORCID 0000-0003-3748-7345
Grigori Y RychkovEpilepsy Research Group, Clinical and Health Sciences, Australian Centre for Precision Health, University of South Australia, Adelaide, SA, 5000, Australia.ORCID 0000-0002-2788-2977
Michael G RicosEpilepsy Research Group, Clinical and Health Sciences, Australian Centre for Precision Health, University of South Australia, Adelaide, SA, 5000, Australia.
Leanne M DibbensEpilepsy Research Group, Clinical and Health Sciences, Australian Centre for Precision Health, University of South Australia, Adelaide, SA, 5000, Australia. Leanne.Dibbens@unisa.edu.au.ORCID 0000-0002-5824-3342
University of South Australia · AUUniversity of Leeds · GBFlinders University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations in the KCNT1 potassium channel cause severe forms of epilepsy which are poorly controlled with current treatments. In vitro studies have shown that KCNT1-epilepsy mutations are gain of function, significantly increasing K

Indexed as

DrosophilaEpilepsyPotassium Channels, Sodium-ActivatedAnimalsDrosophila melanogasterDrug Evaluation, PreclinicalHumansModels, AnimalMutationNerve Tissue ProteinsSeizuresTransgenesKCNT1 protein, humanNerve Tissue ProteinsPotassium Channels, Sodium-Activated

Identifiers

PMID38336906
PMCPMC10858247
OpenAlexW4391684157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.