ArticleNature communications2024
An integrated self-optimizing programmable chemical synthesis and reaction engine.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Vib2Mol: from vibrational spectra to molecular structures-a unified deep learning framework.Chemical science · 2026Article
- Receptogenesis in a Vascularized Robotic Embodiment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- From Eyes to Cameras to Kinetics: Computer Vision for Chemical Process Monitoring.Accounts of chemical research · 2026Article
- Chemputer and chemputation-A universal chemical compound synthesis machine.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Verification and execution of the scientific literature via chemputation augmented by large language models.Communications chemistry · 2026Article
- Antiviral drug discovery and development: challenges and future directions.Signal transduction and targeted therapy · 2026Review
- Article
- Utilizing Similarity Measures to Map Chemical Reactivity.Angewandte Chemie (International ed. in English) · 2026Article
- Lanthanide Nanotheranostics in Radiotherapy.International journal of molecular sciences · 2025Review
- Reac-Discovery: an artificial intelligence-driven platform for continuous-flow catalytic reactor discovery and optimization.Nature communications · 2025Article
- Robotic system takes chemistry into hyperspace.Nature · 2025Article
- Article
- Universal peptide synthesis via solid-phase methods fused with chemputation.Nature communications · 2025Article
- Article
- Artificial Intelligence (AI) Applications in Drug Discovery and Drug Delivery: Revolutionizing Personalized Medicine.Pharmaceutics · 2024Review
- Self-Driving Laboratories for Chemistry and Materials Science.Chemical reviews · 2024Review
- Reaction Kinetics using a Chemputable Framework for Data Collection and Analysis.Angewandte Chemie (International ed. in English) · 2024Article
- An integrated self-optimizing programmable chemical synthesis and reaction engine.Nature communications · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Robotic platforms for chemistry are developing rapidly but most systems are not currently able to adapt to changing circumstances in real-time. We present a dynamically programmable system capable of making, optimizing, and discovering new molecules which utilizes seven sensors that continuously monitor the reaction. By developing a dynamic programming language, we demonstrate the 10-fold scale-up of a highly exothermic oxidation reaction, end point detection, as well as detecting critical hardware failures. We also show how the use of in-line spectroscopy such as HPLC, Raman, and NMR can be used for closed-loop optimization of reactions, exemplified using Van Leusen oxazole synthesis, a four-component Ugi condensation and manganese-catalysed epoxidation reactions, as well as two previously unreported reactions, discovered from a selected chemical space, providing up to 50% yield improvement over 25-50 iterations. Finally, we demonstrate an experimental pipeline to explore a trifluoromethylations reaction space, that discovers new molecules.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.