Evidence map›Paper›PMID 38336872›Full record

ArticleRheumatology (Oxford, England)2024

Lung imaging patterns in connective tissue disease-associated interstitial lung disease impact prognosis and immunosuppression response.

Boyang Zheng, Daniel-Costin Marinescu, Cameron J Hague, Nestor L Muller, Darra Murphy, Andrew Churg, Joanne L Wright, Amna Al-Arnawoot, Ana-Maria Bilawich, Patrick Bourgouin and 31 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Rheumatology (Oxford, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors.

Boyang ZhengDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.
Daniel-Costin MarinescuDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.
Cameron J HagueDepartment of Radiology, University of British Columbia, Vancouver, BC, Canada.
Nestor L MullerDepartment of Radiology, University of British Columbia, Vancouver, BC, Canada.
Darra MurphyDepartment of Radiology, St James' Hospital, Dublin 8, Ireland.
Andrew ChurgDepartment of Pathology, University of British Columbia, Vancouver, BC, Canada.
Joanne L WrightDepartment of Pathology, University of British Columbia, Vancouver, BC, Canada.
Amna Al-ArnawootDepartment of Radiology, McMaster University, Hamilton, ON, Canada.
Ana-Maria BilawichDepartment of Radiology, University of British Columbia, Vancouver, BC, Canada.
Patrick BourgouinDepartment of Radiology, University of Montreal, Montreal, QC, Canada.
Gerard CoxDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Celine DurandDépartement de Médecine, Centre de recherche du Centre hospitalier de l, 'Université de Montréal, Montréal, QC, Canada.
Tracy ElliotDepartment of Radiology, University of Calgary, Calgary, AB, Canada.
Jennifer EllisDepartment of Radiology, University of British Columbia, Vancouver, BC, Canada.
Jolene H FisherDepartment of Medicine, University of Toronto, Toronto, ON, Canada.
Derek FladelandDepartment of Medical Imaging, University of Saskatchewan, Saskatoon, SK, Canada.
Amanda Grant-OrserDepartment of Medicine, University of Calgary, Calgary, AB, Canada.
Gillian C GoobieDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.
Zachary GuentherDepartment of Radiology, University of Calgary, Calgary, AB, Canada.
Ehsan HaiderDepartment of Radiology, McMaster University, Hamilton, ON, Canada.
Nathan HamblyDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
James HuynhDepartment of Radiology, McMaster University, Hamilton, ON, Canada.
Kerri A JohannsonDepartment of Medicine, University of Calgary, Calgary, AB, Canada.
Geoffrey KarjalaDepartment of Medical Imaging, University of Saskatchewan, Saskatoon, SK, Canada.
Nasreen KhalilDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.
Martin KolbDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Jonathon LeipsicDepartment of Radiology, University of British Columbia, Vancouver, BC, Canada.
Stacey D LokDepartment of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
Sarah MacIsaacDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Micheal McInnisDepartment of Medical Imaging, University of Toronto, Toronto, ON, Canada.
Helene ManganasDépartement de Médecine, Centre de recherche du Centre hospitalier de l, 'Université de Montréal, Montréal, QC, Canada.
Veronica MarcouxDepartment of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
John MayoDepartment of Radiology, University of British Columbia, Vancouver, BC, Canada.
Julie MorissetDépartement de Médecine, Centre de recherche du Centre hospitalier de l, 'Université de Montréal, Montréal, QC, Canada.
Ciaran ScallanDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Tony SedlicDepartment of Radiology, University of British Columbia, Vancouver, BC, Canada.
Shane ShaperaDepartment of Medicine, University of Toronto, Toronto, ON, Canada.
Kelly SunDepartment of Medicine, University of Toronto, Toronto, ON, Canada.
Victoria TanDepartment of Radiology, McMaster University, Hamilton, ON, Canada.
Alyson W WongDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.
Christopher J RyersonDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.

Funding

AstraZenecaCanadian Lung AssociationCanadian Pulmonary Fibrosis FoundationCanadian Registry for Pulmonary FibrosisCIHRUniversity Hospital FoundationUniversity of British ColumbiaUniversity of SaskatchewanUniversity of Toronto
6 · The paper itself

Abstract

objectivesInterstitial lung disease (ILD) in CTDs has highly variable morphology. We aimed to identify imaging features and their impact on ILD progression, mortality, and immunosuppression response.

methodsPatients with CTD-ILD had high-resolution chest CT (HRCT) reviewed by expert radiologists blinded to clinical data for overall imaging pattern [usual interstitial pneumonia (UIP); non-specific interstitial pneumonia (NSIP); organizing pneumonia (OP); fibrotic hypersensitivity pneumonitis (fHP); and other]. Transplant-free survival and change in percent-predicted forced vital capacity (FVC) were compared using Cox and linear mixed-effects models adjusted for age, sex, smoking, and baseline FVC. FVC decline after immunosuppression was compared with pre-treatment.

resultsAmong 645 CTD-ILD patients, the most frequent CTDs were SSc (n = 215), RA (n = 127), and inflammatory myopathies (n = 100). NSIP was the most common pattern (54%), followed by UIP (20%), fHP (9%), and OP (5%). Compared with the case for patients with UIP, FVC decline was slower in patients with NSIP (by 1.1%/year, 95% CI 0.2, 1.9) or OP (by 3.5%/year, 95% CI 2.0, 4.9), and mortality was lower in patients with NSIP [hazard ratio (HR) 0.65, 95% CI 0.45, 0.93] or OP (HR 0.18, 95% CI 0.05, 0.57), but higher in fHP (HR 1.58, 95% CI 1.01, 2.40). The extent of fibrosis also predicted FVC decline and mortality. After immunosuppression, FVC decline was slower compared with pre-treatment in NSIP (by 2.1%/year, 95% CI 1.4, 2.8), with no change for UIP or fHP.

conclusionMultiple radiologic patterns are possible in CTD-ILD, including a fHP pattern. NSIP and OP were associated with better outcomes and response to immunosuppression, while fHP had worse survival compared with UIP.

Indexed as

Connective Tissue DiseasesLung Diseases, InterstitialTomography, X-Ray ComputedAdultAgedDisease ProgressionFemaleHumansImmunosuppression TherapyImmunosuppressive AgentsLungMaleMiddle AgedPrognosisRetrospective StudiesVital CapacityImmunosuppressive Agentsconnective tissue diseaseinterstitial lung diseaseprognosisradiologic patterns

Identifiers

PMID38336872
PMCPMC11443038

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.