ArticleNature communications2024
Natural diversity screening, assay development, and characterization of nylon-6 enzymatic depolymerization.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 76 citations in OpenAlex.
- Advances in amidases and urethanases as depolymerization biocatalysts.Nature chemical biology · 2026Review
- Review
- Environmental Identification of Novel Enzymes for Polyurethane and Polyamide Degradation.Angewandte Chemie (International ed. in English) · 2026Article
- Biodegradation of components from an oxidized polyethylene by aApplied and environmental microbiology · 2026Article
- Plastics and Bioplastics End of Life: A Biocatalytic Perspective.Microbial biotechnology · 2026Article
- Trylons: Polyamide Surrogate Substrates Enable High-Throughput Screening of Nylon-Degrading Enzymes.Chembiochem : a European journal of chemical biology · 2026Article
- Reaction Optimization for Enzymatic Deconstruction of Industrially Relevant Nylon Composites.Chembiochem : a European journal of chemical biology · 2026Article
- Application of the YebF secretion pathway inRSC chemical biology · 2026Article
- Challenges and opportunities in the enzymatic recycling of nylons.Nature chemical biology · 2026Review
- Defined Nylon Oligomers Enable Mechanistic Insight Into Enzymatic Polyamide Depolymerization.ChemSusChem · 2026Article
- Microbial and Enzymatic Degradation of Nylon: Mechanisms, Diversity, and Biotechnological Application.Journal of microbiology and biotechnology · 2026Review
- Directed Evolution of an Efficient Polycarbonate Depolymerase With Exceptional Operational Stability.Angewandte Chemie (International ed. in English) · 2026Article
- Extracting Caprolactam from PA6 Waste: Progress in Chemical Recycling and Sustainable Practices.Polymers · 2026Review
- Production and Evaluation of Fluorophore-Doped Polymer Substrates to Screen for Plastic-Degrading Enzymes.ACS sustainable chemistry & engineering · 2026Article
- Structural and oligomeric characterization of substrate- and product-selective nylon hydrolases.bioRxiv : the preprint server for biology · 2026Article
- Microbial plastic degradation: enzymes, pathways, challenges, and perspectives.Microbiology and molecular biology reviews : MMBR · 2025Review
- The discovery of new metagenomic urethanases utilising a novel colorimetric assay for applications in the biodegradation of polyurethanes.Green chemistry : an international journal and green chemistry resource : GC · 2025Article
- Chemoenzymatic cascade depolymerization of plastics.Communications chemistry · 2025Article
- Article
- Iterative Synthesis and Marine-Biodegradation Assessment of Discrete Oligomers Based on Poly(Butylene Succinate), Poly(Ethylene Terephthalate), Polyamide 6, and Polyisoprene.Macromolecules · 2025Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Successes in biocatalytic polyester recycling have raised the possibility of deconstructing alternative polymers enzymatically, with polyamide (PA) being a logical target due to the array of amide-cleaving enzymes present in nature. Here, we screen 40 potential natural and engineered nylon-hydrolyzing enzymes (nylonases), using mass spectrometry to quantify eight compounds resulting from enzymatic nylon-6 (PA6) hydrolysis. Comparative time-course reactions incubated at 40-70 °C showcase enzyme-dependent variations in product distributions and extent of PA6 film depolymerization, with significant nylon deconstruction activity appearing rare. The most active nylonase, a NylC
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.