Evidence map›Paper›PMID 38336828›Full record

ArticleScientific reports2024

Radiation effects on retinal layers revealed by OCT, OCT-A, and perimetry as a function of dose and time from treatment.

Michelle R Tamplin, Jui-Kai Wang, Elaine M Binkley, Mona K Garvin, Daniel E Hyer, John M Buatti, H Culver Boldt, Isabella M Grumbach, Randy H Kardon

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Radiation retinopathy: a review.International ophthalmology · 2026
    Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Michelle R TamplinDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa, Iowa City, IA, USA.
Jui-Kai WangIowa City VA Center for the Prevention and Treatment of Visual Loss, Iowa City, IA, USA.
Elaine M BinkleyDivision of Neuro-Ophthalmology, Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, 52242, USA.
Mona K GarvinIowa City VA Center for the Prevention and Treatment of Visual Loss, Iowa City, IA, USA.
Daniel E HyerDepartment of Radiation Oncology, University of Iowa, Iowa City, IA, USA.
John M BuattiDepartment of Radiation Oncology, University of Iowa, Iowa City, IA, USA.
H Culver BoldtDivision of Neuro-Ophthalmology, Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, 52242, USA.
Isabella M GrumbachDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa, Iowa City, IA, USA.
Randy H KardonIowa City VA Center for the Prevention and Treatment of Visual Loss, Iowa City, IA, USA. randy-kardon@uiowa.edu.
University of Iowa · USIowa City VA Health Care System · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0M
TRAINING PROGRAM IN FREE RADICAL AND RADIATION BIOLOGYT32CA078586 · NCI · UNIVERSITY OF IOWA · PI SPITZ, DOUGLAS ROBERT · 1999 to 2024
$5.7M
Laser speckle flowgraphy as early indicator of microvasculopathy in radiation-induced vision lossR01EY031544 · NEI · UNIVERSITY OF IOWA · PI GRUMBACH, ISABELLA MARIA, KARDON, RANDY H. · 2020 to 2024
$2.8M
Mitochondrial CAMKII in smooth muscle as key regulator of hypertension and vascular remodelingI01BX000163 · VA · OKLAHOMA CITY VA MEDICAL CENTER · PI Isabella Maria Grumbach · 2011 to 2026
–
BLRD VA I01 BX000163NCI NIH HHS P30 CA086862NCI NIH HHS T32 CA078586NEI NIH HHS R01 EY031544
6 · The paper itself

Abstract

Optical coherence tomography (OCT) has become a key method for diagnosing and staging radiation retinopathy, based mainly on the presence of fluid in the central macula. A robust retinal layer segmentation method is required for identification of the specific layers involved in radiation-induced pathology in individual eyes over time, in order to determine damage driven by radiation injury to the microvessels and to the inner retinal neurons. Here, we utilized OCT, OCT-angiography, visual field testing, and patient-specific dosimetry models to analyze abnormal retinal layer thickening and thinning relative to microvessel density, visual function, radiation dose, and time from radiotherapy in a cross-sectional cohort of uveal melanoma patients treated with

Indexed as

Radiation InjuriesRetinal DegenerationRetinal NeuronsCross-Sectional StudiesHumansRetinaTomography, Optical CoherenceVisual Field Tests

Identifiers

PMID38336828
PMCPMC10858219
OpenAlexW4391692981

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.