Evidence map›Paper›PMID 38336823›Full record

ArticleScientific reports2024

Developmental loss of NMDA receptors results in supernumerary forebrain neurons through delayed maturation of transit-amplifying neuroblasts.

Amalia J Napoli, Stephanie Laderwager, Josiah D Zoodsma, Bismi Biju, Olgerta Mucollari, Sarah K Schubel, Christieann Aprea, Aaliya Sayed, Kiele Morgan, Annelysia Napoli and 3 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.1field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Amalia J NapoliDepartment of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY, 11794-5230, USA.ORCID 0000-0002-2603-8563
Stephanie LaderwagerDepartment of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY, 11794-5230, USA.ORCID 0009-0002-6525-5613
Josiah D ZoodsmaDepartment of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY, 11794-5230, USA.ORCID 0000-0002-3014-860X
Bismi BijuDepartment of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY, 11794-5230, USA.
Olgerta MucollariDepartment of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY, 11794-5230, USA.ORCID 0000-0003-3698-6409
Sarah K SchubelDepartment of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY, 11794-5230, USA.
Christieann ApreaDepartment of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY, 11794-5230, USA.
Aaliya SayedDepartment of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY, 11794-5230, USA.
Kiele MorganDepartment of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY, 11794-5230, USA.
Annelysia NapoliDepartment of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY, 11794-5230, USA.
Stephanie FlanaganDepartment of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY, 11794-5230, USA.
Lonnie P WollmuthDepartment of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY, 11794-5230, USA.ORCID 0000-0002-8179-1259
Howard I SirotkinDepartment of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY, 11794-5230, USA. howard.sirotkin@stonybrook.edu.ORCID 0000-0002-1428-867X
Stony Brook University · US

Funding

IRACDA - The New York Consortium for the Advancement of Postdoctoral Scholars (NY CAPS)Phase IIK12GM102778 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI Carol A. Carter, Karian Janice Wright · 2012 to 2026
$13.1M
CELLULAR NEUROPHYSIOLOGY OF THE VERTEBRATE RETINAR01EY003821 · NEI · STATE UNIVERSITY NEW YORK STONY BROOK · PI WOLLMUTH, LONNIE P · 1985 to 2019
$8.1M
Minority Supplement for Noele CertainR01NS088479 · NINDS · STATE UNIVERSITY NEW YORK STONY BROOK · PI WOLLMUTH, LONNIE P · 2015 to 2023
$3.9M
GluN2B Associated Neurodevelopmental DisordersR03HD101767 · NICHD · STATE UNIVERSITY NEW YORK STONY BROOK · PI SIROTKIN, HOWARD I, WOLLMUTH, LONNIE P · 2020 to 2021
$153k
NEI NIH HHS R01 EY003821NICHD NIH HHS R03 HD101767NIGMS NIH HHS K12 GM102778NIH HHS 5R03HD101767NIH HHS K12GM102778NINDS NIH HHS R01 NS088479
6 · The paper itself

Abstract

Developmental neurogenesis is a tightly regulated spatiotemporal process with its dysregulation implicated in neurodevelopmental disorders. NMDA receptors are glutamate-gated ion channels that are widely expressed in the early nervous system, yet their contribution to neurogenesis is poorly understood. Notably, a variety of mutations in genes encoding NMDA receptor subunits are associated with neurodevelopmental disorders. To rigorously define the role of NMDA receptors in developmental neurogenesis, we used a mutant zebrafish line (grin1

Indexed as

Neural Stem CellsReceptors, N-Methyl-D-AspartateAnimalsNeurogenesisNeuronsTelencephalonZebrafishReceptors, N-Methyl-D-AspartateKCC2Neurodevelopmental disordersNeurogenesisNMDA receptorsTransit amplifying cellsZebrafish

Identifiers

PMID38336823
PMCPMC10858180
OpenAlexW4391676876

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.