ArticleNature communications2024
Mechanistic characterization of a Drosophila model of paraneoplastic nephrotic syndrome.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 20 citations in OpenAlex.
- Lipid metabolism of hepatocyte-like cells supports intestinal tumor growth in Drosophila.Nature communications · 2026Article
- Renal coenzyme A (CoA) production from VB5 fuels stem cell proliferation and tumor growth.Nature communications · 2026Article
- Beyond Mice and Men: Alternative Vertebrate and Invertebrate Models in Cancer Biology.Annual review of cancer biology · 2026Article
- Tumour-host interactions in Drosophila: mechanisms in the tumour micro- and macroenvironment.Molecular oncology · 2026Review
- Hepatic ceramide synthesis links systemic inflammation to organelle dysfunction in cancer.bioRxiv : the preprint server for biology · 2025Article
- Hemocytes facilitate interclonal cooperation-induced tumor malignancy by hijacking the innate immune system in Drosophila.The EMBO journal · 2025Article
- Inflammatory crosstalk: systemic gut-kidney interplay aggravates tumor host mortality.The EMBO journal · 2025Article
- Hepatic gluconeogenesis and PDK3 upregulation drive cancer cachexia in flies and mice.Nature metabolism · 2025Article
- FlyRNAi.org 2025 update-expanded resources for new technologies and species.Nucleic acids research · 2025Article
- The Power of Drosophila in Modeling Cancer Cachexia.Advances in experimental medicine and biology · 2025Review
- FlyPhoneDB2: A computational framework for analyzing cell-cell communication inComputational and structural biotechnology journal · 2025Article
- Nonautonomous Regulation of Tumor Growth.Advances in experimental medicine and biology · 2025Review
- Drosophila Intestine as a Model to Study Tumors.Advances in experimental medicine and biology · 2025Review
- Paraneoplastic renal dysfunction in fly cancer models driven by inflammatory activation of stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Hippo effector, Yorkie, is a tumor suppressor in selectProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Insect hormone PTTH regulates lifespan through temporal and spatial activation of NF-κB signaling during metamorphosis.bioRxiv : the preprint server for biology · 2024Article
- Paraneoplastic renal dysfunction in fly cancer models driven by inflammatory activation of stem cells.bioRxiv : the preprint server for biology · 2024Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Paraneoplastic syndromes occur in cancer patients and originate from dysfunction of organs at a distance from the tumor or its metastasis. A wide range of organs can be affected in paraneoplastic syndromes; however, the pathological mechanisms by which tumors influence host organs are poorly understood. Recent studies in the fly uncovered that tumor secreted factors target host organs, leading to pathological effects. In this study, using a Drosophila gut tumor model, we characterize a mechanism of tumor-induced kidney dysfunction. Specifically, we find that Pvf1, a PDGF/VEGF signaling ligand, secreted by gut tumors activates the PvR/JNK/Jra signaling pathway in the principal cells of the kidney, leading to mis-expression of renal genes and paraneoplastic renal syndrome-like phenotypes. Our study describes an important mechanism by which gut tumors perturb the function of the kidney, which might be of clinical relevance for the treatment of paraneoplastic syndromes.
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