Evidence map›Paper›PMID 38336724›Full record

ReviewJournal of cardiothoracic surgery2024

Determinants of survival following heart transplantation in adults with congenital heart disease.

Hüseyin Sicim, Pierre Emmanuel Noly, Suyash Naik, Vikram Sood, Richard G Ohye, Jonathan W Haft, Keith D Aaronson, Francis D Pagani, Ming-Sing Si, Paul C Tang

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PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of cardiothoracic surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hüseyin SicimDepartment of Cardiac Surgery, University of Michigan Frankel Cardiovascular Center, Ann Arbor, MI, USA.
Pierre Emmanuel NolyDepartment of Cardiac Surgery, Université de Montréal, Montréal, QC, Canada.
Suyash NaikDepartment of Cardiac Surgery, University of Michigan Frankel Cardiovascular Center, Ann Arbor, MI, USA.
Vikram SoodDepartment of Cardiac Surgery, University of Michigan Frankel Cardiovascular Center, Ann Arbor, MI, USA.
Richard G OhyeDepartment of Cardiac Surgery, University of Michigan Frankel Cardiovascular Center, Ann Arbor, MI, USA.
Jonathan W HaftDepartment of Cardiac Surgery, University of Michigan Frankel Cardiovascular Center, Ann Arbor, MI, USA.
Keith D AaronsonDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan Frankel Cardiovascular Center, Ann Arbor, MI, USA.
Francis D PaganiDepartment of Cardiac Surgery, University of Michigan Frankel Cardiovascular Center, Ann Arbor, MI, USA.
Ming-Sing SiDepartment of Surgery, Division of Cardiac Surgery, University of California Los Angeles, Los Angeles, CA, USA.
Paul C TangDepartment of Cardiac Surgery, University of Michigan Frankel Cardiovascular Center, Ann Arbor, MI, USA. tang.paul2@mayo.edu.

Funding

Targeting Immune-Responsive Gene 1 (Irg1) and Itaconate for Cardioprotection of the Donor Heart for TransplantationR01HL164416 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Paul Tang · 2022 to 2026
$3.3M
Targeting Mineralocorticoid Receptor Condensates to Optimize Donor Heart PreservationR01HL166140 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Paul Tang · 2023 to 2026
$2.7M
NHLBI NIH HHS R01 HL164416NHLBI NIH HHS R01 HL166140NIH HHS R01HL166140
6 · The paper itself

Abstract

backgroundAdult patients surviving with congenital heart disease (ACHD) is growing. We examine the factors associated with heart transplant outcomes in this challenging population with complex anatomy requiring redo-surgeries.

methodsWe reviewed the United Network for Organ Sharing-Standard Transplant Analysis and Research database and analyzed 35,952 heart transplants from January 1st, 2000, to September 30th, 2018. We compared transplant characteristics for ischemic cardiomyopathy (ICM) (n = 14,236), nonischemic cardiomyopathy (NICM) (n = 20,676), and ACHD (n = 1040). Mean follow-up was 6.20 ± 4.84 years. Kaplan-Meier survival curves and Cox-proportional hazards analysis were used to analyze survival data.

resultsMultivariable analysis confirmed that ACHD was associated greater in-hospital death compared to ICM (HR = 0.54, P < 0.001) and NICM (HR = 0.46, P < 0.001). Notable factors associated with increased mortality were history of cerebrovascular disease (HR = 1.11, P = 0.026), prior history of malignancy (HR = 1.12, P = 0.006), pre-transplant biventricular support (HR = 1.12, P = 0.069), postoperative stroke (HR = 1.47, P < 0.001) and postoperative dialysis (HR = 1.71, P < 0.001). ACHD transplants had a longer donor heart ischemic time (P < 0.001) and trend towards more deaths from primary graft dysfunction (P = 0.07). In-hospital deaths were more likely with ACHD and use of mechanical support such as use of right ventricular assist device (HR = 2.20, P = 0.049), biventricular support (HR = 1.62, P < 0.001) and extracorporeal membrane oxygenation (HR = 2.36, P < 0.001). Conditional survival after censoring hospital deaths was significantly higher in ACHD (P < 0.001).

conclusionHeart transplant in ACHD is associated with a higher post-operative mortality given anatomical complexity but a better long-term conditional survival. Normothermic donor heart perfusion may improve outcomes in the ACHD population by reducing the impact of longer ischemic times.

Indexed as

CardiomyopathiesHeart Defects, CongenitalHeart TransplantationAdultHospital MortalityHumansRetrospective StudiesTissue DonorsCongenital heart diseaseHeart failureHeart transplantOutcomes

Identifiers

PMID38336724
PMCPMC10858543

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.