ArticleBMC cardiovascular disorders2024
Association of systemic inflammatory response index with ST segment elevation myocardial infarction and degree of coronary stenosis: a cross-sectional study.
Article in BMC cardiovascular disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed.
- Age-Dependent Inflammatory, Lipid, and Echocardiographic Phenotypes in Acute Myocardial Infarction: Associations with In-Hospital Adverse Clinical Events.Biomedicines · 2026Article
- Association of systemic inflammation response index and triglyceride-glucose index with the severity of coronary artery stenosis in elderly patients: a retrospective cross-sectional study.Frontiers in cardiovascular medicine · 2026Article
- Association between the systemic inflammation response index and the prognosis of patients with myocardial infarction: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2026Review
- Association between leukocyte-derived composite indices and premature coronary artery disease: a cross-sectional study.BMC cardiovascular disorders · 2025Article
- Beyond Conventional Blood Parameters: Novel Hematologic Indices for Interpretable Artificial Intelligence in Acute Myocardial Infarction.Journal of clinical practice and research · 2025Article
- Comparison of the prognostic value of complete blood count-derived inflammatory markers for long-term outcomes in ST-segment elevation myocardial infarction.Internal and emergency medicine · 2025Article
- Observational
- Association between systemic inflammatory response index and glaucoma incidence from 2005 to 2008.Frontiers in medicine · 2025Article
- Relationship between inflammatory markers and long-term prognosis in ICU patients with acute non-ST-segment elevation myocardial infarction.Frontiers in cardiovascular medicine · 2025Article
- Prevalence of comorbidities and cardiovascular risk factor management in hand osteoarthritis: a cross-sectional study.Rheumatology international · 2024Article
- Article
- The predictive value of the hs-CRP/HDL-C ratio, an inflammation-lipid composite marker, for cardiovascular disease in middle-aged and elderly people: evidence from a large national cohort study.Lipids in health and disease · 2024Article
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7 authors.
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Abstract
backgroundSystemic Inflammatory Response Index (SIRI), a composite inflammatory marker encompassing neutrophils, monocytes, and lymphocytes, has been recognized as a reliable marker of systemic inflammation. This article undertakes an analysis of clinical data from ST-segment Elevation Myocardial Infarction (STEMI) patients, aiming to comprehensively assess the relationship between SIRI, STEMI, and the degree of coronary stenosis.
methodsThe study involved 1809 patients diagnosed with STEMI between the years 2020 and 2023. Univariate and multivariate logistic regression analyses were conducted to evaluate the risk factors for STEMI. Receiver operating characteristic (ROC) curves were generated to determine the predictive power of SIRI and neutrophil-to-lymphocyte ratio (NLR). Spearman correlation analysis was performed to assess the correlation between SIRI, NLR, and the Gensini score (GS).
resultsMultivariate logistic regression analysis showed that the SIRI was the independent risk factor for STEMI (adjusted odds ratio (OR) in the highest quartile = 24.96, 95% confidence interval (CI) = 15.32-40.66, P < 0.001). In addition, there is a high correlation between SIRI and GS (β:28.54, 95% CI: 24.63-32.46, P < 0.001). The ROC curve analysis was performed to evaluate the predictive ability of SIRI and NLR for STEMI patients. The area under the curve (AUC) for SIRI was 0.789. The AUC for NLR was 0.754. Regarding the prediction of STEMI in different gender groups, the AUC for SIRI in the male group was 0.771. The AUC for SIRI in the female group was 0.807. Spearman correlation analysis showed that SIRI exhibited a stronger correlation with GS, while NLR was lower (SIRI: r = 0.350, P < 0.001) (NLR: r = 0.313, P < 0.001).
conclusionThe study reveals a strong correlation between the SIRI and STEMI as well as the degree of coronary artery stenosis. In comparison to NLR, SIRI shows potential in predicting acute myocardial infarction and the severity of coronary artery stenosis. Additionally, SIRI exhibits a stronger predictive capability for female STEMI patients compared to males.
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