Evidence map›Paper›PMID 38336369›Full record

ArticleStroke and vascular neurology2024

Prediction of futile recanalisation after endovascular treatment in acute ischaemic stroke: development and validation of a hybrid machine learning model.

Ximing Nie, Jinxu Yang, Xinxin Li, Tianming Zhan, Dongdong Liu, Hongyi Yan, Yufei Wei, Xiran Liu, Jiaping Chen, Guoyang Gong and 12 more

Abstract readMulticenter StudyValidation Study
In one paragraph

Article in Stroke and vascular neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Ximing NieDepartment of Neurology, Capital Medical University, Beijing, China.ORCID 0000-0002-8380-4076
Jinxu YangSchool of Computer and Communication Engineering, University of Science and Technology, Beijing, China.
Xinxin LiChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Beijing, China.
Tianming ZhanChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Beijing, China.
Dongdong LiuChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Beijing, China.
Hongyi YanChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Beijing, China.
Yufei WeiDepartment of Neurology, Capital Medical University, Beijing, China.ORCID 0000-0002-1822-7372
Xiran LiuDepartment of Neurology, Capital Medical University, Beijing, China.
Jiaping ChenDepartment of Neurology, Capital Medical University, Beijing, China.
Guoyang GongChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Beijing, China.
Zhenzhou WuChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Beijing, China.ORCID 0000-0002-9119-4554
Zhonghua YangDepartment of Neurology, Capital Medical University, Beijing, China.
Miao WenDepartment of Neurology, Capital Medical University, Beijing, China.
Weibin GuDepartment of Radiology, Beijing Tiantan Hospital, Beijing, China.
Yuesong PanDepartment of Neurology, Capital Medical University, Beijing, China.
Yong JiangDepartment of Neurology, Capital Medical University, Beijing, China.ORCID 0000-0001-7700-6054
Xia MengDepartment of Neurology, Capital Medical University, Beijing, China.
Tao LiuKey Laboratory of Biomechanics and Mechanobiology, Ministry of Education, School of Biological Science and Medical Engineering International Research Institute for Multidisciplinary Science, Beihang University, Beijing, China.ORCID 0000-0002-7783-3073
Jian ChengKey Laboratory of Biomechanics and Mechanobiology, Ministry of Education, School of Biological Science and Medical Engineering International Research Institute for Multidisciplinary Science, Beihang University, Beijing, China.
Zixiao LiDepartment of Neurology, Capital Medical University, Beijing, China.ORCID 0000-0002-4713-5418
Zhongrong MiaoDepartment of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Liping LiuDepartment of Neurology, Capital Medical University, Beijing, China lipingsister@gmail.com.ORCID 0000-0003-2943-055X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIdentification of futile recanalisation following endovascular therapy (EVT) in patients with acute ischaemic stroke is both crucial and challenging. Here, we present a novel risk stratification system based on hybrid machine learning method for predicting futile recanalisation.

methodsHybrid machine learning models were developed to address six clinical scenarios within the EVT and perioperative management workflow. These models were trained on a prospective database using hybrid feature selection technique to predict futile recanalisation following EVT. The optimal model was validated and compared with existing models and scoring systems in a multicentre prospective cohort to develop a hybrid machine learning-based risk stratification system for futile recanalisation prediction.

resultsUsing a hybrid feature selection approach, we trained and tested multiple classifiers on two independent patient cohorts (n=1122) to develop a hybrid machine learning-based prediction model. The model demonstrated superior discriminative ability compared with other models and scoring systems (area under the curve=0.80, 95% CI 0.73 to 0.87) and was transformed into a web application (RESCUE-FR Index) that provides a risk stratification system for individual prediction (accessible online at fr-index.biomind.cn/RESCUE-FR/).

conclusionsThe proposed hybrid machine learning approach could be used as an individualised risk prediction model to facilitate adherence to clinical practice guidelines and shared decision-making for optimal candidate selection and prognosis assessment in patients undergoing EVT.

Indexed as

Endovascular ProceduresIschemic StrokeMachine LearningMedical FutilityPredictive Value of TestsAgedAged, 80 and overClinical Decision-MakingDatabases, FactualDecision Support TechniquesFemaleHumansMaleMiddle AgedProspective StudiesReproducibility of ResultsRisk FactorsStrokeThrombectomy

Identifiers

PMID38336369
PMCPMC11791634

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.