Evidence map›Paper›PMID 38336264›Full record

ArticleJournal of substance use and addiction treatment2024

The impact of the 2014 military conflict in the east of Ukraine and the Autonomous Republic of the Crimea among patients receiving opioid agonist therapies.

Anna Meteliuk, Yana Sazonova, Emily Goldmann, Shu Xu, Vadym Liutyi, Tetiana Liakh, Tetiana Spirina, Maryna Lekholetova, Zahedul Islam, Danielle C Ompad

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of substance use and addiction treatment, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anna MeteliukAlliance for Public Health, Kyiv, Ukraine; Department of Social Pedagogy and Social Work, Borys Grinchenko Kyiv University, Kyiv, Ukraine. Electronic address: meteliuk@gmail.com.
Yana SazonovaDivision of Global HIV and TB, U.S. Centers for Disease Control and Prevention, Kyiv, Ukraine.
Emily GoldmannDepartment of Epidemiology, NYU School of Global Public Health, New York, NY, USA; Center for Drug Use and HIV|HCV Research, NYU School of Global Public Health, New York, NY, USA.
Shu XuDepartment of Biostatistics, NYU School of Global Public Health, New York, NY, USA.
Vadym LiutyiDepartment of Social Pedagogy and Social Work, Borys Grinchenko Kyiv University, Kyiv, Ukraine.
Tetiana LiakhDepartment of Social Pedagogy and Social Work, Borys Grinchenko Kyiv University, Kyiv, Ukraine.
Tetiana SpirinaDepartment of Social Pedagogy and Social Work, Borys Grinchenko Kyiv University, Kyiv, Ukraine.
Maryna LekholetovaDepartment of Social Pedagogy and Social Work, Borys Grinchenko Kyiv University, Kyiv, Ukraine.
Zahedul IslamAlliance for Public Health, Kyiv, Ukraine.
Danielle C OmpadDepartment of Epidemiology, NYU School of Global Public Health, New York, NY, USA; Center for Drug Use and HIV|HCV Research, NYU School of Global Public Health, New York, NY, USA.

Funding

Transdisciplinary Theoretical Svnthesis and Development CoreP30DA011041 · NIDA · NEW YORK UNIVERSITY · PI Holly Hagan · 1998 to 2026
$38.9M
Expanding Medication Assisted Therapy in Ukraine (ExMAT)R01DA033679 · NIDA · YALE UNIVERSITY · PI ALTICE, FREDERICK LEWIS · 2012 to 2021
$6.4M
Ukraine HIV Research Training ProgramD43TW010562 · FIC · SUNY DOWNSTATE MEDICAL CENTER · PI DEHOVITZ, JACK A · 2017 to 2021
$1.7M
Ukraine HIV Research Training Program/Aging SupplementD43TW012491 · FIC · SUNY DOWNSTATE MEDICAL CENTER · PI Jack A DeHovitz, Tetiana Kiriazova · 2023 to 2026
$1.0M
FIC NIH HHS D43 TW010562FIC NIH HHS D43 TW012491NIDA NIH HHS P30 DA011041NIDA NIH HHS R01 DA033679
6 · The paper itself

Abstract

backgroundOpioid agonist therapies (OAT) for people with opioid use disorders (OUD) have been available in Ukraine since 2004. This study assessed the effect of 2014 Russian invasion of Ukraine on OAT re-enrollment and retention in conflict areas.

methodsWe analyzed the Ukraine national registry of OAT patients containing 1868 people with OUD receiving OAT as of January 2014 in conflict areas (Donetsk, Luhansk, and the Autonomous Republic [AR] of the Crimea). We developed logistic regression models to assess the correlates of re-enrollment of OAT patients in government-controlled areas (GCA) from conflict areas and retention on OAT at 12 months after re-enrollment.

resultsOverall, 377 (20.2 %) patients were re-enrolled at an OAT site in a GCA from confict areas, of whom 182 (48.3 %) were retained on OAT through 2021. Correlates of re-enrollment were residing in Donetsk (adjusted odds ratios (aOR) = 7.06; 95 % CI: 4.97-10.20) or Luhansk (aOR = 6.20; 95 % CI: 4.38-8.93) vs. AR Crimea; age 18-34 (aOR = 2.03; 95 % CI: 1.07-3.96) or 35-44 (aOR = 2.09; 95 % CI: 1.24-3.71) vs. ≥55 years, and being on optimal (aOR = 1.78; 95 % CI: 1.33-2.39) or high OAT dosing (aOR = 2.76; 95 % CI: 1.93-3.96) vs. low dosing. Correlates of retention were drug use experience 15-19 years (aOR = 3.69; 95 % CI: 1.47-9.49) vs. <14 years of drug use; take-home (aOR = 3.42; 95 % CI: 1.99-5.96) vs. daily on-site dosing, and optimal (aOR = 2.19; 95 % CI:1.05-4.72) vs. low OAT dosing.

conclusionOur study showed that one-fifth of patients were re-enrolled at sites in GCA areas, less than half of re-enrolled patients were retained. Disruption of OAT has implications for drug-, HIV-, and HCV-related morbidity and mortality.

fundingAM was funded by NIH-funded grant D43TW010562; DCO was funded by the NIDA-funded Center for Drug Use and HIV|HCV Research (P30DA011041).

Indexed as

Armed ConflictsOpiate Substitution TreatmentOpioid-Related DisordersAdultAnalgesics, OpioidFemaleHumansMaleMiddle AgedRegistriesRussiaUkraineYoung AdultAnalgesics, OpioidBuprenorphineMethadoneMilitary conflictOpioid agonist therapies (OAT)People with opiod use disorder (OUD)UkraineWar

Identifiers

PMID38336264
PMCPMC11413855

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.