Evidence map›Paper›PMID 38335963›Full record

ArticleStem cell reports2024

Give heart cells a beat: An interactive museum exhibit that synchronizes stem cell-derived cardiomyocytes to visitors' heartbeat.

Juan A Perez-Bermejo, Samuel J Reisman, Joyce Ma, Dana Carrison-Stone, Chris Cerrito, Alexandre J S Ribeiro, Bruce R Conklin, Kristina Yu

Open access · goldAbstract read
In one paragraph

Article in Stem cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Juan A Perez-BermejoGladstone Institutes, San Francisco, CA, USA.
Samuel J ReismanExploratorium, San Francisco, CA, USA.
Joyce MaExploratorium, San Francisco, CA, USA.
Dana Carrison-StoneExploratorium, San Francisco, CA, USA.
Chris CerritoExploratorium, San Francisco, CA, USA.
Alexandre J S RibeiroGladstone Institutes, San Francisco, CA, USA.
Bruce R ConklinGladstone Institutes, San Francisco, CA, USA; Innovative Genomics Institute, Berkeley, CA 94704, USA; University of California, San Francisco Departments of Medicine and Ophthalmology, San Francisco, CA 94143, USA. Electronic address: bconklin@gladstone.ucsf.edu.
Kristina YuExploratorium, San Francisco, CA, USA. Electronic address: kyu@exploratorium.edu.
Exploratorium · USGladstone Institutes · USUniversity of California, San Francisco · US

Funding

Project 3: Control of cardiac transcription by MEF2 and myocardinP01HL146366 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI SRIVASTAVA, DEEPAK · 2019 to 2023
$13.7M
JAX-Gladstone, SCGE Disease Models Studies SupplementU01ES032673 · NIEHS · J. DAVID GLADSTONE INSTITUTES · PI CONKLIN, BRUCE R · 2020 to 2022
$2.4M
Protein quality control, cardiomyopathy, cardiotoxicity and human isogenic iPSCsR01HL135358 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI CONKLIN, BRUCE R · 2017 to 2020
$2.0M
Identifying Therapeutic Targets for RNA Splicing-Related CardiomyopathyR01HL130533 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI CONKLIN, BRUCE R · 2016 to 2019
$1.8M
NHLBI NIH HHS P01 HL146366NHLBI NIH HHS R01 HL130533NHLBI NIH HHS R01 HL135358NIEHS NIH HHS U01 ES032673
6 · The paper itself

Abstract

Science museums play an important role in science education, engaging the public with science concepts and building support for scientific research. Here, we describe Give Heart Cells a Beat, an interactive exhibit that lets museum visitors synchronize the beating of live stem cell-derived cardiomyocytes to their own heart rate in real time. The beat rate of cells accurately matched the beat rate of visitors and responded dynamically to changes such as exercise. Visitor evaluation revealed that engagement with the specimen prompted curiosity in heart biology and stem cells. Give Heart Cells a Beat is the product of a close collaboration between a museum and an academic research laboratory, and to our knowledge, it is the first interactive exhibit to use live human heart cells. We hope this exhibit serves as an example for the implementation of stem cell technology in informal science education and inspires future relationships between academia and public science venues.

Indexed as

MuseumsMyocytes, CardiacHeart RateHumansStem Cellscardiomyocyteheart beatinteractive museum exhibitiPSC

Identifiers

PMID38335963
PMCPMC10937149
OpenAlexW4391643822

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.