ArticlePsychiatry research2024
Genetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disorders.
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Article in Psychiatry research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
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Who cites it
5 citing papers in PubMed, 16 citations in OpenAlex.
- Causal inference in psychiatric research: how to critically evaluate and interpret mendelian randomization studies.Molecular psychiatry · 2026Review
- The mediating role of anxiety and depression symptoms in the relationship between ADHD symptoms and polysubstance use among French university students: the i-share study.Addictive behaviors reports · 2026Article
- From genes to networks: neurobiological bases of neurodiversity across common developmental disorders.Frontiers in neuroscience · 2026Review
- Differences and similarities between the genetic architecture of lifetime substance use across different substances.Psychological medicine · 2025Article
- Complex Attention-Deficit Hyperactivity Disorder in a 15-year-old With a Substance Use Disorder.Journal of developmental and behavioral pediatrics : JDBPArticle
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Authors and funding
24 authors at 9 institutions in 4 countries.
Dora KollerDepartment of Psychiatry, Yale School of Medicine, New Haven, CA, USA; Veterans Affairs Connecticut Healthcare Center, West Haven, CA, USA; Department of Genetics, Microbiology, and Statistics, Faculty of Biology, University of Barcelona, Catalonia, Spain. Electronic address: dora.koller@yale.edu.
Marina MitjansDepartment of Genetics, Microbiology, and Statistics, Faculty of Biology, University of Barcelona, Catalonia, Spain; Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Institute of Biomedicine of the University of Barcelona (IBUB), Barcelona, Catalonia Spain; Sant Joan de Déu Research Institute (IR-SJD), Esplugues de Llobregat, Catalonia, Spain.
Manuela KouakouDepartment of Psychiatry, Yale School of Medicine, New Haven, CA, USA.
Eleni FriligkouDepartment of Psychiatry, Yale School of Medicine, New Haven, CA, USA; Veterans Affairs Connecticut Healthcare Center, West Haven, CA, USA.
Brenda Cabrera-MendozaDepartment of Psychiatry, Yale School of Medicine, New Haven, CA, USA; Veterans Affairs Connecticut Healthcare Center, West Haven, CA, USA.
Joseph D DeakDepartment of Psychiatry, Yale School of Medicine, New Haven, CA, USA; Veterans Affairs Connecticut Healthcare Center, West Haven, CA, USA.
Natalia LlongaPsychiatric Genetics Unit, Group of Psychiatry Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
Gita A PathakDepartment of Psychiatry, Yale School of Medicine, New Haven, CA, USA; Veterans Affairs Connecticut Healthcare Center, West Haven, CA, USA.
Brendan StiltnerDepartment of Psychiatry, Yale School of Medicine, New Haven, CA, USA; Veterans Affairs Connecticut Healthcare Center, West Haven, CA, USA.
Solveig LøkhammerDepartment of Psychiatry, Yale School of Medicine, New Haven, CA, USA; NORMENT, Department of Clinical Science, University of Bergen, Bergen, Norway; Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
Daniel F LeveyDepartment of Psychiatry, Yale School of Medicine, New Haven, CA, USA; Veterans Affairs Connecticut Healthcare Center, West Haven, CA, USA.
Hang ZhouDepartment of Psychiatry, Yale School of Medicine, New Haven, CA, USA; Veterans Affairs Connecticut Healthcare Center, West Haven, CA, USA.
Alexander S HatoumDepartment of Psychological and Brain Sciences, Washington University in Saint Louis, St. Louis, MO, USA.
Rachel L KemberDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Mental Illness Research, Education and Clinical Center, Veterans Integrated Service Network 4, Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA.
Henry R KranzlerDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Mental Illness Research, Education and Clinical Center, Veterans Integrated Service Network 4, Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA.
Murray B SteinDepartment of Psychiatry, University of California, San Diego, La Jolla, USA; Herbert Wertheim School of Public Health, University of California, San Diego, La Jolla, USA; VA San Diego Healthcare System, San Diego, CA, La Jolla, USA.
Roser CorominasDepartment of Genetics, Microbiology, and Statistics, Faculty of Biology, University of Barcelona, Catalonia, Spain; Institute of Biomedicine of the University of Barcelona (IBUB), Barcelona, Catalonia Spain; Sant Joan de Déu Research Institute (IR-SJD), Esplugues de Llobregat, Catalonia, Spain; Biomedical Network Research Centre on Rare Disorders (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.
Ditte DemontisDepartment of Biomedicine - Human Genetics, Aarhus University, Aarhus, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Center for Genomics and Personalized Medicine, Aarhus, Denmark; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
María Soler ArtigasDepartment of Genetics, Microbiology, and Statistics, Faculty of Biology, University of Barcelona, Catalonia, Spain; Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Psychiatric Genetics Unit, Group of Psychiatry Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain; Department of Mental Health, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Josep Antoni Ramos-QuirogaDepartment of Genetics, Microbiology, and Statistics, Faculty of Biology, University of Barcelona, Catalonia, Spain; Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Psychiatric Genetics Unit, Group of Psychiatry Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain; Department of Psychiatry and Forensic Medicine, Universitat Autonoma de Barcelona, Barcelona, Spain.
Joel GelernterDepartment of Psychiatry, Yale School of Medicine, New Haven, CA, USA; Veterans Affairs Connecticut Healthcare Center, West Haven, CA, USA; Department of Genetics, Yale School of Medicine, New Haven, CT, USA; Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA.
Marta RibasésDepartment of Genetics, Microbiology, and Statistics, Faculty of Biology, University of Barcelona, Catalonia, Spain; Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Psychiatric Genetics Unit, Group of Psychiatry Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain; Department of Mental Health, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Bru CormandDepartment of Genetics, Microbiology, and Statistics, Faculty of Biology, University of Barcelona, Catalonia, Spain; Institute of Biomedicine of the University of Barcelona (IBUB), Barcelona, Catalonia Spain; Sant Joan de Déu Research Institute (IR-SJD), Esplugues de Llobregat, Catalonia, Spain; Biomedical Network Research Centre on Rare Disorders (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.
Renato PolimantiDepartment of Psychiatry, Yale School of Medicine, New Haven, CA, USA; Veterans Affairs Connecticut Healthcare Center, West Haven, CA, USA; Wu Tsai Institute, Yale University, New Haven, CT, USA.
Yale University · USUniversitat Autònoma de Barcelona · ESInstituto de Salud Carlos III · ESVeterans Health Administration · USBroad Institute · USCentre for Biomedical Network Research on Rare Diseases · ESHaukeland University Hospital · NOUC San Diego Health System · USWashington University in St. Louis · US
Funding
RESEARCH TRAINING - BIOLOGICAL SCIENCEST32MH014276 · NIMH · YALE UNIVERSITY · PI Marina R Picciotto · 1985 to 2026
$7.2MLeveraging genomic data to dissect the association of internalizing disorders with the risk, onset, and vulnerability of COVID-19RF1MH132337 · NIMH · YALE UNIVERSITY · PI POLIMANTI, RENATO · 2022 to 2022
$3.7MInvestigating the Systems Genetics of the Patterns of Polysubstance Abuse and AddictionR33DA047527 · NIDA · YALE UNIVERSITY · PI POLIMANTI, RENATO · 2021 to 2023
$2.0MTranslational Alcohol Research Program (TARP)T32AA028259 · NIAAA · YALE UNIVERSITY · PI COSGROVE, KELLY P., VASILIOU, VASILIS · 2020 to 2024
$1.8MIdentifying genetic sources of comorbidity between cannabis and schizophrenia using genome-wide and integrative omics dataK01DA051759 · NIDA · WASHINGTON UNIVERSITY · PI JOHNSON, EMMA COVEY · 2021 to 2025
$816kGenome-wide Investigation of the Interplay Between Age-Related Hearing Loss and Smoking BehaviorsR21DC018098 · NIDCD · YALE UNIVERSITY · PI POLIMANTI, RENATO · 2019 to 2021
$440kMulti-modal intersection of depression and genetic liability to Alzheimers diseaseK99AG078503 · NIA · YALE UNIVERSITY · PI PATHAK, GITA A · 2022 to 2023
$203kGenomics of PTSD and Related TraitsI01CX001849 · VA · VA CONNECTICUT HEALTHCARE SYSTEM · PI GELERNTER, JOEL, STEIN, MURRAY B. · 2019 to 2022
–Investigating the Genomic Architecture of Anxiety and Overlap with Mental Health Disorders in the Million Veteran Program.IK2BX005058 · VA · VA CONNECTICUT HEALTHCARE SYSTEM · PI LEVEY, DANIEL F · 2021 to 2025
–BLRD VA IK2 BX005058CSRD VA I01 CX001849NIAAA NIH HHS T32 AA028259NIA NIH HHS K99 AG078503NIDA NIH HHS K01 DA051759NIDA NIH HHS R33 DA047527NIDCD NIH HHS R21 DC018098NIMH NIH HHS RF1 MH132337NIMH NIH HHS T32 MH014276
Abstract
We characterized the genetic architecture of the attention-deficit hyperactivity disorder-substance use disorder (ADHD-SUD) relationship by investigating genetic correlation, causality, pleiotropy, and common polygenic risk. Summary statistics from genome-wide association studies (GWAS) were used to investigate ADHD (N
Indexed as
AlcoholismAttention Deficit Disorder with HyperactivityOpioid-Related DisordersSubstance-Related DisordersComorbidityGenome-Wide Association StudyHumansAttention-deficit hyperactivity disorderMendelian randomizationPleiotropyPolygenic risk scoringSubstance use disorders
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