Evidence map›Paper›PMID 38335253›Full record

ArticleJournal of applied clinical medical physics2024

An IMRT planning technique for treating whole breast or chest wall with regional lymph nodes on Halcyon and Ethos.

Kareem Rayn, Ryan Clark, Klea Hoxha, Anthony Magliari, Jack Neylon, Michael H Xiang, Dylan P O'Connell

Abstract read
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Article in Journal of applied clinical medical physics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Kareem RaynVarian Medical Affairs, Palo Alto, California, USA.
Ryan ClarkVarian Medical Affairs, Palo Alto, California, USA.
Klea HoxhaDepartment of Radiation Oncology, University of California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0003-1309-7246
Anthony MagliariVarian Medical Affairs, Palo Alto, California, USA.
Jack NeylonDepartment of Radiation Oncology, University of California, Los Angeles, California, USA.
Michael H XiangDepartment of Radiation Oncology, University of California, Los Angeles, California, USA.
Dylan P O'ConnellDepartment of Radiation Oncology, University of California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-0752-5825

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PURPOSE/

objectiveField size limitations on Halcyon and Ethos treatment machines largely preclude use of the conventional monoisocentric three-field technique for breast/chest wall and regional lymph nodes. We present an alternative, IMRT-based planning approach that facilitates treatment on Halcyon and Ethos while preserving plan quality. MATERIALS/

methodsEight breast and regional node cases (four left-sided, four right-sided) were planned for an Ethos machine using a 15-17 field IMRT technique. Institutional plan quality metrics for CTV and PTV coverage and OAR sparing were assessed. Five plans (four right-sided, one left-sided) were also planned using a hybrid 3D multisocenter technique. CTV coverage and OAR sparing were compared to the IMRT plans. Eclipse scripting tools were developed to aid in beam placement and plan evaluation through a set of dosimetric scorecards, and both are shared publicly.

resultsOn average, the IMRT plans achieved breast CTV and PTV coverage at 50 Gy of 97.9% and 95.7%, respectively. Supraclavicular CTV and PTV coverages at 45 Gy were 100% and 95.5%. Axillary lymph node CTV and PTV coverages at 45 Gy were 100% and 97.1%, and IMN CTV coverage at 45 Gy was 99.2%. Mean ipsilateral lung V20 Gy was 19.3%, and average mean heart dose was 1.6 Gy for right-sided cases and 3.0 Gy for left-sided. In comparison to the hybrid 3D plans, IMRT plans achieved higher breast and supraclavicular CTV coverage (99.9% vs. 98.6% and 99.9% vs. 93.4%), higher IMN coverage (99.6% vs. 78.2%), and lower ipsilateral lung V20 Gy (19.6% vs. 28.2%).

conclusionInstitutional plan quality benchmarks were achieved for all eight cases using the IMRT-based planning approach. The IMRT-based planning approach offered superior conformity and OAR sparing than a competing hybrid 3D approach.

Indexed as

Breast NeoplasmsLymph NodesOrgans at RiskRadiotherapy DosageRadiotherapy, Intensity-ModulatedRadiotherapy Planning, Computer-AssistedThoracic WallFemaleHumansbreast IMRTEthosHalcyon

Identifiers

PMID38335253
PMCPMC11087171

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.