Evidence map›Paper›PMID 38334912›Full record

ArticleInternational urology and nephrology2024

The impact of malnutrition on the effectiveness of intradialytic exercise in hemodialysis patients: amulticenter cohort study.

Ren Takahashi, Hiroki Yabe, Hideaki Ishikawa, Takashi Hibino, Sayumi Morishita, Kenichi Kono, Yoshifumi Moriyama, Tetsuya Yamada

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Article in International urology and nephrology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Ren TakahashiDepartment of Rehabilitation, Kaikoukai Josai Hospital, Nagoya, Aichi, Japan. 16RP24@g.seirei.ac.jp.ORCID http://orcid.org/0000-0003-0860-7352
Hiroki YabeDepartment of Physical Therapy, School of Rehabilitation Sciences, Seirei Christopher University, Hamamatsu, Shizuka, Japan.
Hideaki IshikawaDepartment of Internal Medicine, Kaikoukai Josai Hospital, Nagoya, Aichi, Japan.
Takashi HibinoDepartment of Rehabilitation, Kaikoukai Josai Hospital, Nagoya, Aichi, Japan.
Sayumi MorishitaDepartment of Rehabilitation, Kaikoukai Josai Hospital, Nagoya, Aichi, Japan.
Kenichi KonoDepartment of Physical Therapy, International University of Health and Welfare School of Health Science at Narita, Narita, Chiba, Japan.
Yoshifumi MoriyamaDepartment of Wellness Center, Nagoya Kyoritsu Hospital, Nagoya, Aichi, Japan.
Tetsuya YamadaDialysis Division, Kaikoukai Healthcare Group, Nagoya, Aichi, Japan.
Nagoya Ekisaikai Hospital · JPSeirei Christopher University · JPHiroshima Kyoritsu Hospital · JPInternational University of Health and Welfare · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeLow physical function can be effectively improved via intradialytic exercise. However, the association between the effects of intradialytic exercise on physical function and malnutrition severity has not been studied extensively. This study aimed to investigate the impact of nutritional status severity on physical function in patients undergoing hemodialysis with low physical function to whom intradialytic exercise was prescribed.

methodsThe participants were patients with decreased mobility [walking speed < 1.0 m/s and/or Short Physical Performance Battery (SPPB) < 12] who had been undergoing hemodialysis thrice a week for 6 months and performing intradialytic exercise program. Patients were divided into groups based on the Geriatric Nutritional Risk Index (GNRI) [Non-malnutrition group (GNRI > 98), Gentle/slim malnutrition group (GNRI ≤ 98, GNRI ≥ 92), Mild malnutrition group (GNRI < 92, GNRI ≥ 82), Severe malnutrition group (GNRI < 82)]. The primary outcomes were Grip strength, isometric knee extension strength (IKES), SPPB, and 10-m walking speed measured at baseline and at 6 months. Statistical analyses were performed using a linear mixed-effects model with the intention-to-treat analysis, including within-group analysis and between-group comparison.

resultsA total of 805 participants were included in the study. Within-group comparisons showed significantly improved IKES, 10-m walking speed, and SPPB improved, except in the Severe malnutrition group. Grip strength significantly improved in the Gentle/slim and mild malnutrition groups. Between-group comparison with controls showed that the improvement in Grip strength was significantly bigger in the Gentle/slim malnutrition group [0.98 (0.15 to 1.82) kg] than in the non-malnutrition group. However, IKES in the Severe malnutrition group [- 5.14 (- 9.18 to - 1.10) %] less significantly improve than that in the non-malnutrition group. No significant differences were found in the other indices.

conclusionIn patients with severe malnutrition, the changes in IKES scores resulting from Intradialytic exercise were significantly smaller than those observed in non-malnourished patients. Therefore, it is necessary to initiate suitable nutritional and exercise therapy based on the severity of malnutrition.

Indexed as

MalnutritionRenal DialysisAgedCohort StudiesExercise TherapyFemaleHumansKidney Failure, ChronicMaleMiddle AgedNutritional StatusProspective StudiesTreatment OutcomeExerciseHemodialysisLow physical functionMalnutrition

Identifiers

PMID38334912
OpenAlexW4391678898

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.