Evidence map›Paper›PMID 38334911›Full record

ReviewInternational urology and nephrology2024

The factors that are associated with itching in chronic kidney patients and evaluation of itching with the 5d itch scale.

Barıs Mulla Cetin, Fatma Betul Guzel, Ilyas Ozturk, Ertugrul Erken, Ozkan Gungor, Orcun Altunoren

Abstract readReview
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In one paragraph

Review in International urology and nephrology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Barıs Mulla CetinFaculty of Medicine, Department of Nephrology, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.ORCID http://orcid.org/0000-0001-8725-7949
Fatma Betul GuzelFaculty of Medicine, Department of Nephrology, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.ORCID http://orcid.org/0000-0003-1569-9654
Ilyas OzturkFaculty of Medicine, Department of Nephrology, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.ORCID http://orcid.org/0000-0001-9431-8068
Ertugrul ErkenFaculty of Medicine, Department of Nephrology, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.ORCID http://orcid.org/0000-0002-7054-1203
Ozkan GungorFaculty of Medicine, Department of Nephrology, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.ORCID http://orcid.org/0000-0003-1861-5452
Orcun AltunorenFaculty of Medicine, Department of Nephrology, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey. orcunaltunoren@hotmail.com.ORCID http://orcid.org/0000-0002-8913-4341

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveUremic pruritus is a distressing complication of chronic kidney disease (CKD), associated with mortality, and negatively impacts quality of life. The 5D-Itch Scale (5D-IS) is an easy-to-apply technique that evaluates 5 different dimensions of itching such as duration, severity, course, disability, and prevalence. We aimed to investigate the prevalence of itching in different CKD stages using the 5D-IS and to investigate the factors associated with itching in CKD patients. MATERIALS AND

methods5D-IS was used to evaluate itching in chronic hemodialysis (HD) and Stage 3-5 CKD patients. Total itching score and sub-scores consist of duration, severity, course, disability and distribution were obtained. Itching scores and prevalence according to CKD stages were investigated. Also the relationships between itching scores and some laboratory and clinical parameters such as iPTH, Ca, P, CRP levels were examined.

results158 CKD patients included in the study included (110 Stage 3-5 and 48 HD). The frequency of itching was higher in HD patients than in predialysis patients (62.5% vs 46.4%; p = 0.04). The total itching score increased along with CKD stages 3 to 5 (7.75 ± 3.39, 7.82 ± 4.11 and 9.08 ± 5.12 respectively; p = 0.14). The severity, duration and course scores of itching were similar between the groups, but the distribution scores increased as the CKD stage increased. The laboratory and clinical characteristics of patients with and without itching were not different. Even if a significant positive correlation was detected between the parathyroid hormone levels and both the total 5D-IS scores and all of the sub-scores, Ca and P values were not correlated with itching scores. In the multiple regression analysis, the only parameter that had an effect on the total 5D-IS Score was the parathyroid hormone level.

conclusionIn CKD, itching affects 40-70% of patients from the early stages. As the CKD stage increases, itching spreads throughout the body. The only parameter that seems to be associated with itching is the PTH level.

Indexed as

PruritusRenal DialysisRenal Insufficiency, ChronicSeverity of Illness IndexAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedParathyroid HormonePrevalenceParathyroid Hormone5D Itch scaleEnd-Stage renal diseaseHemodialysisUremic pruritus

Identifiers

PMID38334911

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.