Evidence map›Paper›PMID 38334670›Full record

ArticleCells2024

Filamin C Deficiency Impairs Sarcomere Stability and Activates Focal Adhesion Kinase through PDGFRA Signaling in Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Shanshan Gao, Lingaonan He, Chi Keung Lam, Matthew R G Taylor, Luisa Mestroni, Raffaella Lombardi, Suet Nee Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Filamin C activates MAPK/ERK signaling to facilitate epithelial-mesenchymal transition in bladder cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  3. Review
  4. Case Report: Filamin-C (Frontiers in medicine · 2026
    Article
  5. Dilated Cardiomyopathy: A Genetic Journey from Past to Future.International journal of molecular sciences · 2024
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Shanshan GaoUniversity of Colorado Cardiovascular Institute, University of Colorado-Anschutz Medical and Boulder Campuses, Aurora, CO 80045, USA.ORCID 0000-0003-4194-3630
Lingaonan HeUniversity of Colorado Cardiovascular Institute, University of Colorado-Anschutz Medical and Boulder Campuses, Aurora, CO 80045, USA.
Chi Keung LamDepartment of Biological Sciences, University of Delaware, Newark, NE 19716, USA.ORCID 0000-0003-4565-9426
Matthew R G TaylorUniversity of Colorado Cardiovascular Institute, University of Colorado-Anschutz Medical and Boulder Campuses, Aurora, CO 80045, USA.ORCID 0000-0001-9043-0810
Luisa MestroniUniversity of Colorado Cardiovascular Institute, University of Colorado-Anschutz Medical and Boulder Campuses, Aurora, CO 80045, USA.ORCID 0000-0003-1116-2286
Raffaella LombardiUniversity of Colorado Cardiovascular Institute, University of Colorado-Anschutz Medical and Boulder Campuses, Aurora, CO 80045, USA.ORCID 0000-0001-5025-6993
Suet Nee ChenUniversity of Colorado Cardiovascular Institute, University of Colorado-Anschutz Medical and Boulder Campuses, Aurora, CO 80045, USA.ORCID 0000-0002-9519-9416
University of Colorado Anschutz Medical Campus · USUniversity of Delaware · US

Funding

POSTGRADUATE TRAINING IN CARDIOVASCULAR RESEARCHT32HL007822 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BUTTRICK, PETER N., LEINWAND, LESLIE ANNE · 1996 to 2023
$6.2M
Engineering Cardiac spheroids to study LaminopathiesR01HL164634 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Luisa Mestroni, Matthew R Taylor · 2023 to 2026
$2.8M
Cardiomyocyte phenotype and mechanotransduction in Filamin C gene variants causing arrhythmogenic cardiomyopathyR01HL147064 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MESTRONI, LUISA, TAYLOR, MATTHEW R · 2020 to 2023
$2.1M
NHLBI NIH HHS R01 HL147064NHLBI NIH HHS R01 HL164634NHLBI NIH HHS T32 HL007822NIH HHS R01HL147064NIH HHS T32 5T32HL007822-23
6 · The paper itself

Abstract

Truncating mutations in filamin C (

Indexed as

CardiomyopathiesFilaminsInduced Pluripotent Stem CellsFocal Adhesion Protein-Tyrosine KinasesHumansMyocytes, CardiacReceptor Protein-Tyrosine KinasesSarcomeresSignal TransductionFilaminsFLNC protein, humanFocal Adhesion Protein-Tyrosine KinasesReceptor Protein-Tyrosine Kinasescrenolanibdilated cardiomyopathyfilamin CPDGFRA

Identifiers

PMID38334670
PMCPMC10854597
OpenAlexW4391471560

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.