Evidence map›Paper›PMID 38334649›Full record

ArticleCells2024

A Cataract-Causing Mutation in the TRPM3 Cation Channel Disrupts Calcium Dynamics in the Lens.

Yuefang Zhou, Thomas M Bennett, Philip A Ruzycki, Zhaohua Guo, Yu-Qing Cao, Mohammad Shahidullah, Nicholas A Delamere, Alan Shiels

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Through theGenes · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yuefang ZhouDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-8517-1292
Thomas M BennettDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-8867-1110
Philip A RuzyckiDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-3520-6407
Zhaohua GuoDepartment of Anesthesiology and Washington University Pain Center, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-9586-5688
Yu-Qing CaoDepartment of Anesthesiology and Washington University Pain Center, Washington University School of Medicine, St. Louis, MO 63110, USA.
Mohammad ShahidullahDepartment of Physiology, University of Arizona College of Medicine, Tucson, AZ 85724, USA.ORCID 0000-0002-1142-4242
Nicholas A DelamereDepartment of Physiology, University of Arizona College of Medicine, Tucson, AZ 85724, USA.ORCID 0000-0002-3018-1645
Alan ShielsDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-4610-596X
University of Arizona · USWashington University in St. Louis · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
WASHINGTON UNIVERSITY CENTER VISION RESEARCHP30EY002687 · NEI · WASHINGTON UNIVERSITY · PI Steven Bassnett · 1985 to 2026
$18.4M
TRPV4 as a remote controller of lens functionR01EY009532 · NEI · UNIVERSITY OF LOUISVILLE · PI DELAMERE, NICHOLAS A · 1993 to 2024
$8.0M
Regulation of Trigeminal Nociception by TRESK ChannelsR01NS103350 · NINDS · WASHINGTON UNIVERSITY · PI CAO, YUQING · 2018 to 2022
$2.5M
Hemichannels, TRPV4 and a mechanosensitive form of autocrine regulation in the NPER01EY029171 · NEI · UNIVERSITY OF ARIZONA · PI DELAMERE, NICHOLAS A · 2019 to 2023
$2.2M
TRP-CHANNELS IN LENS DEVELOPMENT AND CATARACTR01EY028899 · NEI · WASHINGTON UNIVERSITY · PI SHIELS, ALAN · 2019 to 2023
$1.9M
NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NEI NIH HHS P30 EY002687NEI NIH HHS R01 EY009532NEI NIH HHS R01 EY028899NEI NIH HHS R01 EY029171NIH HHS EY028899, EY02687, NS103350, EY009532NINDS NIH HHS R01 NS103350
6 · The paper itself

Abstract

TRPM3 belongs to the melastatin sub-family of transient receptor potential (TRPM) cation channels and has been shown to function as a steroid-activated, heat-sensitive calcium ion (Ca

Indexed as

CataractMicroRNAsTransient Receptor Potential ChannelsTRPM Cation ChannelsAnimalsCalciumCationsHumansMiceMutationCalciumCationsMicroRNAsMIRN204 microRNA, humanTransient Receptor Potential ChannelsTRPM3 protein, humanTRPM3 protein, mouseTRPM Cation Channelscalciumcataractgene expressionlensmiR-204/211TRPM3

Identifiers

PMID38334649
PMCPMC10854584
OpenAlexW4391353040

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.