Evidence map›Paper›PMID 38334631›Full record

ArticleCells2024

Novel Vitamin D3 Hydroxymetabolites Require Involvement of the Vitamin D Receptor or Retinoic Acid-Related Orphan Receptors for Their Antifibrogenic Activities in Human Fibroblasts.

Zorica Janjetovic, Shariq Qayyum, Sivani B Reddy, Ewa Podgorska, S Gates Scott, Justyna Szpotan, Alisa A Mobley, Wei Li, Vijay K Boda, Senthilkumar Ravichandran and 3 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. The vitamin DAmerican journal of physiology. Cell physiology · 2025
    Article
  6. Review
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Zorica JanjetovicDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0001-6108-2212
Shariq QayyumDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0003-0777-1994
Sivani B ReddyDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Ewa PodgorskaDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0002-1550-0871
S Gates ScottDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0002-8845-9136
Justyna SzpotanDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Alisa A MobleyDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0002-0979-6987
Wei LiCollege of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0002-9522-4474
Vijay K BodaCollege of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0001-7299-2369
Senthilkumar RavichandranDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Robert C TuckeySchool of Molecular Science, The University of Western Australia, Perth 6009, Australia.ORCID 0000-0002-5022-4729
Anton M JettenCell Biology Section, NIEHS, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Andrzej T SlominskiDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0001-8963-3995
University of Alabama at Birmingham · USUniversity of Tennessee Health Science Center · USBrigham and Women's Hospital · USNational Institutes of Health · USThe University of Western Australia · AU

Funding

Nuclear receptors: action, functions, and roles in diseaseZIAES101586 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI JETTEN, ANTON M · 2009 to 2025
$13.5M
Nuclear receptors--Action, functions, &roles in diseaseZ01ES101586 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI JETTEN, ANTON M · 2003 to 2008
$3.2M
Mechanism of action and function of novel secosteroid 20(OH)D3 in the skinR01AR073004 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ANDRZEJ T SLOMINSKI · 2018 to 2026
$2.9M
Significance of metabolic activation of lumisterol in the skinR01AR071189 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SLOMINSKI, ANDRZEJ T · 2017 to 2021
$1.6M
Canonical and non-canonical vitamin D activation pathways in systemic lupusR21AI149267 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RAMAN, CHANDER, SLOMINSKI, ANDRZEJ T · 2020 to 2021
$408k
CYP11A1-derived secosteroids as therapeutic agents in UVB induced skin cancerI01BX004293 · VA · BIRMINGHAM VA MEDICAL CENTER · PI SLOMINSKI, ANDRZEJ T · 2019 to 2025
–
BLRD VA I01 BX004293Intramural NIH HHS Z01 ES101586NIAID NIH HHS R21 AI149267NIAMS NIH HHS R01 AR071189NIAMS NIH HHS R01 AR073004NIH HHS 1R01AR073004NIH HHS R01AR071189NIH HHS R21AI149267-01A1
6 · The paper itself

Abstract

We investigated multiple signaling pathways activated by CYP11A1-derived vitamin D3 hydroxymetabolites in human skin fibroblasts by assessing the actions of these molecules on their cognate receptors and by investigating the role of CYP27B1 in their biological activities. The actions of 20(OH)D3, 20,23(OH)

Indexed as

CholecalciferolReceptors, Calcitriol25-Hydroxyvitamin D3 1-alpha-HydroxylaseCollagenFibroblastsHumansReceptors, Retinoic AcidTretinoin25-Hydroxyvitamin D3 1-alpha-HydroxylaseCholecalciferolCollagenReceptors, CalcitriolReceptors, Retinoic AcidTretinoinfibroblastsmetabolitesretinoic acid-related orphan receptorsvitamin D3vitamin D receptor

Identifiers

PMID38334631
PMCPMC10854953
OpenAlexW4391254903

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.