Evidence map›Paper›PMID 38334601›Full record

ArticleCells2024

The Role of CCL24 in Primary Sclerosing Cholangitis: Bridging Patient Serum Proteomics to Preclinical Data.

Raanan Greenman, Tom Snir, Avi Katav, Revital Aricha, Inbal Mishalian, Ophir Hay, Matthew Frankel, John Lawler, Francesca Saffioti, Massimo Pinzani and 4 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Myeloid cells in chronic liver inflammation.Cellular & molecular immunology · 2025
    Review
  5. Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Raanan GreenmanChemomab Therapeutics Ltd., Tel Aviv 6158002, Israel.ORCID 0009-0001-9634-4638
Tom SnirChemomab Therapeutics Ltd., Tel Aviv 6158002, Israel.
Avi KatavChemomab Therapeutics Ltd., Tel Aviv 6158002, Israel.
Revital ArichaChemomab Therapeutics Ltd., Tel Aviv 6158002, Israel.
Inbal MishalianGoldyne Savad Institute of Gene Therapy, Hebrew University Hospital Jerusalem, Jerusalem 91120, Israel.
Ophir HayGoldyne Savad Institute of Gene Therapy, Hebrew University Hospital Jerusalem, Jerusalem 91120, Israel.
Matthew FrankelChemomab Therapeutics Ltd., Tel Aviv 6158002, Israel.ORCID 0009-0006-4321-9055
John LawlerChemomab Therapeutics Ltd., Tel Aviv 6158002, Israel.
Francesca SaffiotiUCL Institute for Liver and Digestive Health, University College of London, London NW3 2PF, UK.ORCID 0000-0001-7635-9931
Massimo PinzaniUCL Institute for Liver and Digestive Health, University College of London, London NW3 2PF, UK.
Douglas ThorburnUCL Institute for Liver and Digestive Health, University College of London, London NW3 2PF, UK.
Amnon PeledGoldyne Savad Institute of Gene Therapy, Hebrew University Hospital Jerusalem, Jerusalem 91120, Israel.
Adi MorChemomab Therapeutics Ltd., Tel Aviv 6158002, Israel.
Ilan VakninChemomab Therapeutics Ltd., Tel Aviv 6158002, Israel.
Biokine (Israel) · ILHebrew University of Jerusalem · ILRoyal Free London NHS Foundation Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary sclerosing cholangitis (PSC) is an inflammatory and fibrotic biliary disease lacking approved treatment. We studied CCL24, a chemokine shown to be overexpressed in damaged bile ducts, and its involvement in key disease-related mechanisms. Serum proteomics of PSC patients and healthy controls (HC) were analyzed using the Olink

Indexed as

Cholangitis, SclerosingCholestasisAnimalsBile DuctsChemokine CCL24FibrosisHumansMiceProteomicsCCL24 protein, humanChemokine CCL24CCL24chemokinescholangitisfibrosishepatic stellate cellsinflammationmonocytesneutrophilsproteomics

Identifiers

PMID38334601
PMCPMC10854794
OpenAlexW4391137382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.