ArticleNanomaterials (Basel, Switzerland)2024
Dentine Remineralisation Induced by "Bioactive" Materials through Mineral Deposition: An In Vitro Study.
Article in Nanomaterials (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Role of Regulatory T Cells in Periodontitis With or Without Systemic Diseases: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Bioactive inorganic materials in dental resin infiltrants: a systematic and critical review of their effects on infiltrant properties and tooth surfaces.Clinical oral investigations · 2025Pooled it
- Calcium silicate liner versus no liner in selective caries removal: a one-year randomized clinical trial.BMC oral health · 2026Trial
- Development of an experimental pulp capping material containing antibacterial and remineralizing peptide: an in vitro study.BMC oral health · 2026Article
- Advanced Biomaterials for Restorative Dentistry: From Biocompatibility to Bioactive and Smart Materials.Bioengineering (Basel, Switzerland) · 2026Review
- Bioactive restorative materials in dentistry: a comprehensive review of mechanisms, clinical applications, and future directions.Odontology · 2026Review
- Clinical and Laboratory Performance of ACTIVA BioACTIVE Restorative in Primary Teeth: A Systematic Review of Pediatric Evidence.Journal of clinical medicine · 2026Review
- Bioactive and Ion-releasing materials in minimum intervention dentistry: a clinical pathway from prevention to restorative treatment.Frontiers in dental medicine · 2026Article
- Comparison of mineral precipitation, elemental release, pH change and cytotoxicity of calcium-silicate cements and an experimental resin-modified glass ionomer cement containing bioactive glass.Biomaterial investigations in dentistry · 2026Article
- Advances in Bioactive Dental Adhesives for Caries Prevention: A State-of-the-Art Review.Journal of functional biomaterials · 2025Review
- Comparison of remineralization in caries-affected dentin using calcium silicate, glass ionomer cement, and resin-modified glass ionomer cement: an in vitro study.Restorative dentistry & endodontics · 2025Article
- Bioactivity and biocompatibility of bioceramic-based pulp capping materials in laboratory and animal models.Journal of materials science. Materials in medicine · 2025Article
- Water Absorption and Solubility of Fluoride-Based Restorative Materials Exposed to Ionizing Radiation.Polymers · 2025Article
- Bioactive Resin Cement Color Stability and Restoration Thickness as Determinants of the Final Shade in a Glass-Ceramic CAD/CAM Material.Journal of functional biomaterials · 2025Article
- Comparative Evaluation of Color Stability in Bioactive and Conventional Resin Cements Under Thermal Stress Conditions.Biomimetics (Basel, Switzerland) · 2025Article
- Fluoride Release from Pediatric Dental Restorative Materials: A Laboratory Investigation.Dentistry journal · 2025Article
- Microstructural and Elemental Characterization of Calcium Silicate-Based Sealers.Nanomaterials (Basel, Switzerland) · 2025Article
- Mechanical properties of modern restorative "bioactive" dental materials - an in vitro study.Scientific reports · 2025Article
- Influence of Academic Training and Professional Experience on the Management of Deep Caries Lesions.Healthcare (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to assess the ability of modern resin-based "bioactive" materials (RBMs) to induce dentine remineralisation via mineral deposition and compare the results to those obtained with calcium silicate cements (CSMs). The following materials were employed for restoration of dentine cavities: CSMs: ProRoot MTA (Dentsply Sirona), MTA Angelus (Angelus), Biodentine (Septodont), and TheraCal LC (Bisco); RBMs: ACTIVA BioACTIVE Base/Liner (Pulpdent), ACTIVA Presto (Pulpdent), and Predicta Bioactive Bulk (Parkell). The evaluation of the mineral deposition was performed through scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX) on the material and dentine surfaces, as well as at the dentine-material interface after immersion in simulated body fluid. Additionally, the Ca/P ratios were also calculated in all the tested groups. The specimens were analysed after setting (baseline) and at 24 h, 7, 14, and 28 days. ProRoot MTA, MTA Angelus, Biodentine, and TheraCal LC showed significant surface precipitation, which filled the gap between the material and the dentine. Conversely, the three RBMs showed only a slight ability to induce mineral precipitation, although none of them was able to remineralise the dentine-material interface. In conclusion, in terms of mineral precipitation, modern "bioactive" RBMs are not as effective as CSMs in inducing dentine remineralisation; these latter represent the only option to induce a possible reparative process at the dentin-material interface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.