ReviewBrain : a journal of neurology2024
A neuroanatomical and cognitive model of impaired social behaviour in frontotemporal dementia.
Review in Brain : a journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Neuroimaging Meta-Analyses Reveal Convergence of Interoception, Emotion, and Social Cognition Across Neurodegenerative Diseases.Biological psychiatry · 2025Pooled it
- The orbitofrontal-anterior temporal network complements the attention network for where to look in social situations.eNeuro · 2026Article
- Emotional brain responses and pattern expressions in right temporal variant frontotemporal dementia.Journal of neurology · 2026Article
- The presymptomatic and early manifestations of semantic dementia.Brain : a journal of neurology · 2026Article
- The neural bases of frontotemporal dementia and primary progressive aphasia subtypes: insights from activation likelihood estimation meta-analyses of 8057 patients.Brain communications · 2026Review
- Clinical recognition of frontotemporal dementia with right temporal predominance: a consensus statement from the International Working Group.Communications medicine · 2025Review
- Dynamic face-related eye movement representations in the human ventral pathway.Communications biology · 2025Article
- Factors Associated with the Social Behaviour of People with Alzheimer's Dementia: A Video Observation Study.Brain sciences · 2025Article
- Neural signatures and personalized neuromodulation in a subject experiencing context-dependent inhibitory control deficits.NeuroImage · 2025Article
- Functional connectivity of semantic and default mode networks during narrative comprehension.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Understanding the mind-brain relationship through focal neurodegenerative pathology.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- Destination memory in behavioral-variant frontotemporal dementia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Behavioural changes in frontotemporal dementia and their cognitive and neuroanatomical correlates.Brain : a journal of neurology · 2025Article
- The unity/diversity framework of executive functions: behavioral and neural evidence in older adults.GeroScience · 2025Article
- The inferior fronto-occipital fasciculus: bridging phylogeny, ontogeny and functional anatomy.Brain : a journal of neurology · 2025Review
- Mental State Recognition Deficits Linked to Brain Changes in Parkinson's Disease Without Dementia.The European journal of neuroscience · 2025Article
- Neurodegenerative Disorders in Criminal Offending and Cognitive Decline Among Aging Inmates.NeuroSci · 2025Review
- Network changes associated with right anterior temporal lobe atrophy: insight into unique symptoms.Brain communications · 2025Article
- Social-semantic knowledge in frontotemporal dementia and after anterior temporal lobe resection.Brain communications · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Impaired social cognition is a core deficit in frontotemporal dementia (FTD). It is most commonly associated with the behavioural-variant of FTD, with atrophy of the orbitofrontal and ventromedial prefrontal cortex. Social cognitive changes are also common in semantic dementia, with atrophy centred on the anterior temporal lobes. The impairment of social behaviour in FTD has typically been attributed to damage to the orbitofrontal cortex and/or temporal poles and/or the uncinate fasciculus that connects them. However, the relative contributions of each region are unresolved. In this review, we present a unified neurocognitive model of controlled social behaviour that not only explains the observed impairment of social behaviours in FTD, but also assimilates both consistent and potentially contradictory findings from other patient groups, comparative neurology and normative cognitive neuroscience. We propose that impaired social behaviour results from damage to two cognitively- and anatomically-distinct components. The first component is social-semantic knowledge, a part of the general semantic-conceptual system supported by the anterior temporal lobes bilaterally. The second component is social control, supported by the orbitofrontal cortex, medial frontal cortex and ventrolateral frontal cortex, which interacts with social-semantic knowledge to guide and shape social behaviour.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.