Evidence map›Paper›PMID 38334469›Full record

ArticleeLife2024

Altered hierarchical auditory predictive processing after lesions to the orbitofrontal cortex.

Olgerta Asko, Alejandro Omar Blenkmann, Sabine Liliana Leske, Maja Dyhre Foldal, Anais LLorens, Ingrid Funderud, Torstein R Meling, Robert T Knight, Tor Endestad, Anne-Kristin Solbakk

Open access · goldAbstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Cortical deviance detection represents a canonical difference signal.bioRxiv : the preprint server for biology · 2026
    Article
  3. Predictive encoding of auditory sequences in the human prefrontal cortex.bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

Olgerta AskoRITMO Centre for Interdisciplinary Studies in Rhythm, Time and Motion, Department of Psychology, University of Oslo, Oslo, Norway.ORCID https://orcid.org/0000-0003-3608-3621
Alejandro Omar BlenkmannRITMO Centre for Interdisciplinary Studies in Rhythm, Time and Motion, Department of Psychology, University of Oslo, Oslo, Norway.ORCID https://orcid.org/0000-0002-8671-2214
Sabine Liliana LeskeRITMO Centre for Interdisciplinary Studies in Rhythm, Time and Motion, Department of Musicology, University of Oslo, Oslo, Norway.
Maja Dyhre FoldalRITMO Centre for Interdisciplinary Studies in Rhythm, Time and Motion, Department of Psychology, University of Oslo, Oslo, Norway.
Anais LLorensHelen Wills Neuroscience Institute and Department of Psychology, University of California, Berkeley, Berkeley, United States.ORCID https://orcid.org/0000-0002-5842-6798
Ingrid FunderudDepartment of Neuropsychology, Helgeland Hospital, Mosjøen, Norway.
Torstein R MelingDepartment of Neurosurgery, National Hospital, Copenhagen, Denmark.
Robert T KnightHelen Wills Neuroscience Institute and Department of Psychology, University of California, Berkeley, Berkeley, United States.
Tor EndestadRITMO Centre for Interdisciplinary Studies in Rhythm, Time and Motion, Department of Psychology, University of Oslo, Oslo, Norway.
Anne-Kristin SolbakkRITMO Centre for Interdisciplinary Studies in Rhythm, Time and Motion, Department of Psychology, University of Oslo, Oslo, Norway.
University of Oslo · NOOslo University Hospital · NOInserm · FRNational Hospital · INUniversity of California, Berkeley · US

Funding

Project 5: ComputationalP50MH109429 · NIMH · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI Michael Peter Milham · 2017 to 2026
$25.3M
Attention, Orientation and the Human Prefrontal CortexR01NS021135 · NINDS · UNIVERSITY OF CALIFORNIA DAVIS · PI Robert Thomas Knight · 1985 to 2026
$6.5M
ATTENTION, ORIENTATION, & THE HUMAN PREFRONTAL CORTEXR37NS021135 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI KNIGHT, ROBERT THOMAS · 2013 to 2019
$3.6M
NIMH NIH HHS P50 MH109429NINDS NIH HHS Conte Center PO 518 MH109429NINDS NIH HHS NINDS R37NS21135NINDS NIH HHS R01 NS021135NINDS NIH HHS R37 NS021135
6 · The paper itself

Abstract

Orbitofrontal cortex (OFC) is classically linked to inhibitory control, emotion regulation, and reward processing. Recent perspectives propose that the OFC also generates predictions about perceptual events, actions, and their outcomes. We tested the role of the OFC in detecting violations of prediction at two levels of abstraction (i.e., hierarchical predictive processing) by studying the event-related potentials (ERPs) of patients with focal OFC lesions (n = 12) and healthy controls (n = 14) while they detected deviant sequences of tones in a local-global paradigm. The structural regularities of the tones were controlled at two hierarchical levels by rules defined at a local (i.e.,

Indexed as

Auditory CortexEvoked Potentials, AuditoryAcoustic StimulationAuditory PerceptionElectroencephalographyHumansPrefrontal Cortexattentionauditory perceptionbrain damageEEGhumanmeningiomaneuroscienceprediction

Identifiers

PMID38334469
PMCPMC10876214
OpenAlexW4391679370

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.