Evidence map›Paper›PMID 38334331›Full record

ReviewEpilepsia open2024

Myoclonus: Differential diagnosis and current management.

Antonella Riva, Gianluca D'Onofrio, Edoardo Ferlazzo, Angelo Pascarella, Elena Pasini, Silvana Franceschetti, Ferruccio Panzica, Laura Canafoglia, Aglaia Vignoli, Antonietta Coppola and 9 more

Open access · goldAbstract readReview
In one paragraph

Review in Epilepsia open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
15.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
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  3. Navigating diagnostic overlap between seizures and movement disorders: A practical clinical approach.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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  19. Adult-Onset Myoclonus: Comparisons and Contrasts in the Inpatient and Outpatient Settings.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025
    Article
  20. A Case Report of Abdominal Myoclonus Following Anterior Cerebral Artery Stroke.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 11 institutions in 1 country.

Antonella RivaDepartment of Neurosciences Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.ORCID https://orcid.org/0000-0001-9152-5571
Gianluca D'OnofrioDepartment of Neurosciences Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.ORCID https://orcid.org/0000-0003-4987-5919
Edoardo FerlazzoDepartment of Medical and Surgical Sciences, Magna Græcia University of Catanzaro, Catanzaro, Italy.
Angelo PascarellaDepartment of Medical and Surgical Sciences, Magna Græcia University of Catanzaro, Catanzaro, Italy.ORCID https://orcid.org/0000-0002-0085-9494
Elena PasiniIRCCS-Istituto delle Scienze Neurologiche di Bologna, Unit of Neurology, Bellaria Hospital, Bologna, Italy.ORCID https://orcid.org/0000-0001-6298-455X
Silvana FranceschettiDepartment of Diagnostics and Technology, Fondazione IRCCS Istituto Neurologio Carlo Besta, Milan, Italy.
Ferruccio PanzicaDepartment of Diagnostics and Technology, Fondazione IRCCS Istituto Neurologio Carlo Besta, Milan, Italy.
Laura CanafogliaDepartment of Diagnostics and Technology, Fondazione IRCCS Istituto Neurologio Carlo Besta, Milan, Italy.ORCID https://orcid.org/0000-0002-5385-761X
Aglaia VignoliChildhood and Adolescence Neurology and Psychiatry Unit, ASST GOM Niguarda, Health Sciences Department, Università degli Studi di Milano, Milano, Italy.
Antonietta CoppolaDepartment of Neuroscience, Odontostomatology and Reproductive Sciences, Federico II University of Naples, Naples, Italy.ORCID https://orcid.org/0000-0002-4845-4293
Valeria BadioniNeurology Unit, ASST Lodi, Lodi, Italy.
Francesca BeccariaASST di Lodi, Lodi, Italy.
Angelo LabateNeurophysiology and Movement Disorders Unit, University of Messina, Messina, Italy.ORCID https://orcid.org/0000-0002-8827-7324
Antonio GambardellaDepartment of Medical and Surgical Sciences, Magna Græcia University of Catanzaro, Catanzaro, Italy.ORCID https://orcid.org/0000-0001-7384-3074
Antonino RomeoPediatric Neurology Unit and Epilepsy Center, Department of Neuroscience, "Fatebenefratelli e Oftalmico" Hospital, Milano, Italy.ORCID https://orcid.org/0000-0001-6172-1766
Giuseppe CapovillaFondazione Poliambulanza, Brescia, Italy.
Roberto MichelucciIRCCS-Istituto delle Scienze Neurologiche di Bologna, Unit of Neurology, Bellaria Hospital, Bologna, Italy.
Pasquale StrianoDepartment of Neurosciences Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.ORCID https://orcid.org/0000-0002-6065-1476
Vincenzo BelcastroNeurology Unit, ASST Lodi, Lodi, Italy.
Fondazione IRCCS Istituto Neurologico Carlo Besta · ITIstituto Giannina Gaslini · ITMagna Graecia University · ITAziende Socio Sanitarie Territoriale LodiIstituto delle Scienze Neurologiche di Bologna · ITAzienda Ospedaliera Fatebenefratelli e Oftalmico · ITFederico II University Hospital · ITFondazione Poliambulanza Istituto Ospedaliero · ITOspedale Maggiore di Lodi · ITUniversity of Messina · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myoclonus classically presents as a brief (10-50 ms duration), non-rhythmic jerk movement. The etiology could vary considerably ranging from self-limited to chronic or even progressive disorders, the latter falling into encephalopathic pictures that need a prompt diagnosis. Beyond the etiological classification, others evaluate myoclonus' body distribution (i.e., clinical classification) or the location of the generator (i.e., neurophysiological classification); particularly, knowing the anatomical source of myoclonus gives inputs on the observable clinical patterns, such as EMG bursts duration or EEG correlate, and guides the therapeutic choices. Among all the chronic disorders, myoclonus often presents itself as a manifestation of epilepsy. In this context, myoclonus has many facets. Myoclonus occurs as one, or the only, seizure manifestation while it can also present as a peculiar type of movement disorder; moreover, its electroclinical features within specific genetically determined epileptic syndromes have seldom been investigated. In this review, following a meeting of recognized experts, we provide an up-to-date overview of the neurophysiology and nosology surrounding myoclonus. Through the dedicated exploration of epileptic syndromes, coupled with pragmatic guidance, we aim to furnish clinicians and researchers alike with practical advice for heightened diagnostic management and refined treatment strategies. PLAIN LANGUAGE SUMMARY: In this work, we described myoclonus, a movement characterized by brief, shock-like jerks. Myoclonus could be present in different diseases and its correct diagnosis helps treatment.

Indexed as

EpilepsyEpileptic SyndromesMovement DisordersMyoclonusDiagnosis, DifferentialHumanselectroclinical featuresepilepsymyoclonusneurophysiologynosology

Identifiers

PMID38334331
PMCPMC10984309
OpenAlexW4391681956

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.