Evidence map›Paper›PMID 38334308›Full record

ArticleAdvanced healthcare materials2024

Natural Polymer-Polyphenol Bioadhesive Coacervate with Stable Wet Adhesion, Antibacterial Activity, and On-Demand Detachment.

Margarida M A Sacramento, Mariana B Oliveira, José R B Gomes, João Borges, Benjamin R Freedman, David J Mooney, João M M Rodrigues, João F Mano

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Biodegradable Adhesive Systems for Bio-Integrated Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Margarida M A SacramentoCICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago, Aveiro, 3810-193, Portugal.ORCID 0000-0003-2257-3371
Mariana B OliveiraCICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago, Aveiro, 3810-193, Portugal.ORCID 0000-0002-6104-6075
José R B GomesCICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago, Aveiro, 3810-193, Portugal.ORCID 0000-0001-5993-1385
João BorgesCICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago, Aveiro, 3810-193, Portugal.ORCID 0000-0003-0126-8482
Benjamin R FreedmanJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA.ORCID 0000-0001-9406-773X
David J MooneyJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA.ORCID 0000-0001-6299-1194
João M M RodriguesCICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago, Aveiro, 3810-193, Portugal.ORCID 0000-0002-4031-8000
João F ManoCICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago, Aveiro, 3810-193, Portugal.ORCID 0000-0002-2342-3765
University of Aveiro · PTBeth Israel Deaconess Medical Center · USHarvard University · US

Funding

Supplement Multifunctional Tough Adhesive Hydrogels to Recruit, Expand, and Deliver Tendon Cells During Aging and InjuryR00AG065495 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Benjamin Ross Freedman · 2023 to 2026
$842k
Multifunctional tough adhesive hydrogels to recruit, expand, and deliver tendoncells during aging and injuryK99AG065495 · NIA · HARVARD UNIVERSITY · PI FREEDMAN, BENJAMIN ROSS · 2020 to 2022
$341k
On-Demand Stem Cell Delivery Systems for Tendon Healing Throughout AgingF32AG057135 · NIA · HARVARD UNIVERSITY · PI FREEDMAN, BENJAMIN ROSS · 2017 to 2019
$155k
Fundação para a Ciência e a Tecnologia UIDB/50011/2020;UIDP/50011/2020;LA/P/0006/2020HORIZON EUROPE Framework Programme 101079482 ("SUPRALIFE")NIA NIH HHS F32 AG057135NIA NIH HHS K99 AG065495NIA NIH HHS R00 AG065495Secretaria Regional do Mar, Ciência e Tecnologia FA_05_2017_031
6 · The paper itself

Abstract

Medical adhesives are emerging as an important clinical tool as adjuvants for sutures and staples in wound closure and healing and in the achievement of hemostasis. However, clinical adhesives combining cytocompatibility, as well as strong and stable adhesion in physiological conditions, are still in demand. Herein, a mussel-inspired strategy is explored to produce adhesive coacervates using tannic acid (TA) and methacrylate pullulan (PUL-MA). TA|PUL-MA coacervates mainly comprise van der Waals forces and hydrophobic interactions. The methacrylic groups in the PUL backbone increase the number of interactions in the adhesives matrix, resulting in enhanced cohesion and adhesion strength (72.7 Jm

Indexed as

Anti-Bacterial AgentsTanninsAdhesivesAnimalsEscherichia coliGlucansHumansMethacrylatesMicePolymersPolyphenolsTissue AdhesivesAdhesivesAnti-Bacterial AgentsGlucansMethacrylatesPolymersPolyphenolspullulanTanninsTissue Adhesivesantibacterialbioadhesivecoacervatecytocompatiblesupramoleculartannic acid

Identifiers

PMID38334308
PMCPMC11469155
OpenAlexW4391682512

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.