Evidence map›Paper›PMID 38333992›Full record

ArticleStroke2024

Association of HIV and HCV Infection With Carotid Artery Plaque Echomorphology in the MACS/WIHS Combined Cohort Study.

Claudio A Bravo, Jee-Young Moon, Krista Davy, Robert C Kaplan, Kathryn Anastos, Carlos J Rodriguez, Wendy S Post, Stephen J Gange, Seble G Kassaye, Lawrence A Kingsley and 10 more

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Stroke, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.1field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 13 institutions in 3 countries.

Claudio A BravoDivision of Cardiology, Department of Medicine, University of Washington, Seattle (C.A.B.).ORCID 0000-0002-7561-052X
Jee-Young MoonDepartment of Epidemiology & Population Health (J.-Y.M., R.C.K., K.A., D.B.H.), Albert Einstein College of Medicine, Bronx, NY.ORCID 0000-0001-9218-8335
Krista DavyCUNY School of Medicine, New York, NY (C.J.R., K.D.).
Robert C KaplanDepartment of Epidemiology & Population Health (J.-Y.M., R.C.K., K.A., D.B.H.), Albert Einstein College of Medicine, Bronx, NY.ORCID 0000-0003-1571-4615
Kathryn AnastosDepartment of Epidemiology & Population Health (J.-Y.M., R.C.K., K.A., D.B.H.), Albert Einstein College of Medicine, Bronx, NY.ORCID 0000-0002-0769-6405
Carlos J RodriguezCUNY School of Medicine, New York, NY (C.J.R., K.D.).ORCID 0000-0003-0860-9008
Wendy S PostDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (W.S.P.).ORCID 0000-0002-8655-5204
Stephen J GangeDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (W.S.P., S.J.G.).ORCID 0000-0001-7842-512X
Seble G KassayeDepartment of Medicine, Georgetown University Medical Center, Washington, DC (S.G.K.).ORCID 0000-0002-7527-7384
Lawrence A KingsleyDepartment of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, PA (L.A.K.).ORCID 0000-0002-7000-8556
Jason M LazarDivision of Cardiovascular Medicine, State University of New York Downstate Medical Center, Brooklyn (J.M.L.).ORCID 0000-0002-8548-7932
Wendy J MackDepartment of Population and Public Health Sciences (W.J.M.), Keck School of Medicine, University of Southern California, Los Angeles.
Nataliya PyslarDivision of Cardiology, Cook County Health, Chicago, IL (N.P.).
Phyllis C TienDepartment of Medicine, University of California-San Francisco, and Department of Veterans Affairs Medical Center, San Francisco, CA (P.C.T.).ORCID 0000-0003-3867-6770
Mallory D WittDivision of HIV Medicine, Lundquist Institute for Biomedical Research at Harbor-UCLA Medical Center, Los Angeles, CA (M.D.W.).ORCID 0000-0002-6366-4029
Frank J PalellaDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL (F.J.P.).
Yanjie LiAtherosclerosis Research Unit (Y.L., M.Y., H.N.H.), Keck School of Medicine, University of Southern California, Los Angeles.ORCID 0009-0003-7648-5833
Mingzhu YanAtherosclerosis Research Unit (Y.L., M.Y., H.N.H.), Keck School of Medicine, University of Southern California, Los Angeles.
Howard N HodisAtherosclerosis Research Unit (Y.L., M.Y., H.N.H.), Keck School of Medicine, University of Southern California, Los Angeles.
David B HannaDepartment of Epidemiology & Population Health (J.-Y.M., R.C.K., K.A., D.B.H.), Albert Einstein College of Medicine, Bronx, NY.ORCID 0000-0002-1985-9865
Albert Einstein College of Medicine · USUniversity of Southern California · USJohns Hopkins University · USCook County Health and Hospitals System · USCUNY School of Law · USGeorgetown University · USNorthwestern University · USSan Francisco VA Medical Center · USSUNY Downstate Health Sciences University · USUCLA Medical Center · USUniversidad Nacional Experimental Simón Rodríguez · VEUniversity of Pittsburgh · USUniversity of Washington · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Aadia Rana · 1988 to 2026
$84.1M
Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
MULTICENTER AIDS COHORT STUDYU01AI035039 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WOLINSKY, STEVEN M · 1993 to 2018
$66.4M
QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
SF Bay Area MACS/WIHS Combined Cohort StudyU01HL146242 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Bradley E Aouizerat, Jennifer Cohen Price · 2019 to 2026
$36.3M
Sex differences in the role of multi-omicsin HIV-associated carotid artery atherosclerosisU01HL146193 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Stephen J Gange, Elizabeth Topper · 2019 to 2026
$35.8M
University of Miami Developmental Center for AIDS Research (D-CFAR)P30AI073961 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GWENDOLYN Barbara SCOTT · 2007 to 2026
$33.8M
Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center - Admin Supplement: Vision and dual sensory loss in HIV-infected older adultsU01HL146201 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TODD T BROWN, Joseph B. Margolick · 2019 to 2026
$33.7M
NCATS NIH HHS KL2 TR001432NCATS NIH HHS TL1 TR001431NCATS NIH HHS UL1 TR000004NCATS NIH HHS UL1 TR001409NCATS NIH HHS UL1 TR001881NCATS NIH HHS UL1 TR003098NHLBI NIH HHS K01 HL137557NHLBI NIH HHS R01 HL083760NHLBI NIH HHS R01 HL095129NHLBI NIH HHS R01 HL095140NHLBI NIH HHS R01 HL125053NHLBI NIH HHS R01 HL126543NHLBI NIH HHS R01 HL140976NHLBI NIH HHS R01 HL144937NHLBI NIH HHS R01 HL148094NHLBI NIH HHS U01 HL146193NHLBI NIH HHS U01 HL146194NHLBI NIH HHS U01 HL146201NHLBI NIH HHS U01 HL146202NHLBI NIH HHS U01 HL146204NHLBI NIH HHS U01 HL146205NHLBI NIH HHS U01 HL146208NHLBI NIH HHS U01 HL146240NHLBI NIH HHS U01 HL146242NHLBI NIH HHS U01 HL146245NHLBI NIH HHS U01 HL146333NIAID NIH HHS P30 AI027767NIAID NIH HHS P30 AI050409NIAID NIH HHS P30 AI050410NIAID NIH HHS P30 AI051519NIAID NIH HHS P30 AI073961NIAID NIH HHS U01 AI035039NIA NIH HHS R21 AG060860NIDA NIH HHS L30 DA017071NIMH NIH HHS P30 MH116867NIMH NIH HHS P30 MH133399
6 · The paper itself

Abstract

backgroundHIV and hepatitis C virus (HCV) are associated with increased risk of carotid artery atherosclerotic plaque and stroke. We examined associations of HIV- and HCV-related factors with echomorphologic features of carotid artery plaque.

methodsThis cross-sectional study included participants from the MACS (Multicenter AIDS Cohort Study)/WIHS (Women's Interagency HIV Study) Combined Cohort Study who underwent high-resolution B-mode carotid artery ultrasound. Plaques were characterized from 6 areas of the right carotid artery. Poisson regression controlling for demographic and cardiometabolic risk factors determined adjusted prevalence ratios (aPRs) and 95% CIs for associations of HIV- and HCV-related factors with echomorphologic features.

resultsOf 2655 participants (65% women, median age 44 [interquartile range, 37-50] years), 1845 (70%) were living with HIV, 600 (23%) were living with HCV, and 425 (16%) had carotid plaque. There were 191 plaques identified in 129 (11%) women with HIV, 51 plaques in 32 (7%) women without HIV, 248 plaques in 171 (28%) men with HIV, and 139 plaques in 93 (29%) men without HIV. Adjusted analyses showed that people with HIV and current CD4

conclusionsHIV with poor immunologic control, as well as HCV infection, either alone or in the presence of HIV, were associated with different echomorphologic phenotypes of carotid artery plaque.

Indexed as

Carotid Artery DiseasesCarotid StenosisCoinfectionHepatitis CHIV InfectionsPlaque, AtheroscleroticAdultCohort StudiesCross-Sectional StudiesFemaleHepacivirusHumansMaleMiddle AgedMulticenter Studies as TopicRisk Factorsatherosclerosiscarotid arterieshepatitis CHIV infectionsstroke

Identifiers

PMID38333992
PMCPMC10940210
OpenAlexW4391684328

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.