Evidence map›Paper›PMID 38333676›Full record

ArticleFrontiers in aging neuroscience2024

To what extent does frailty mediate the association between age and the outcomes of brain reperfusion following acute ischemic stroke?

Luana Aparecida Miranda, Gustavo José Luvizutto, Pedro Augusto Cândido Bessornia, Natalia Eduarda Furlan, Fernanda Cristina Winckler, Natalia Cristina Ferreira, Pedro Tadao Hamamoto Filho, Juli Thomaz de Souza, Luis Cuadrado Martin, Silméia Garcia Zanati Bazan and 4 more

Abstract read
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In one paragraph

Article in Frontiers in aging neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Observational
  3. Frailty and stroke: Global implications for assessment, research, and clinical care-A WSO scientific statement.International journal of stroke : official journal of the International Stroke Society · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Luana Aparecida MirandaDepartment of Neurology, Psychology, and Psychiatry, Botucatu Medical School, São Paulo State University, Botucatu, São Paulo, Brazil.
Gustavo José LuvizuttoDepartment of Applied Physical Therapy, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil.
Pedro Augusto Cândido BessorniaDepartment of Neurology, Psychology, and Psychiatry, Botucatu Medical School, São Paulo State University, Botucatu, São Paulo, Brazil.
Natalia Eduarda FurlanDepartment of Neurology, Psychology, and Psychiatry, Botucatu Medical School, São Paulo State University, Botucatu, São Paulo, Brazil.
Fernanda Cristina WincklerDepartment of Neurology, Psychology, and Psychiatry, Botucatu Medical School, São Paulo State University, Botucatu, São Paulo, Brazil.
Natalia Cristina FerreiraDepartment of Neurology, Psychology, and Psychiatry, Botucatu Medical School, São Paulo State University, Botucatu, São Paulo, Brazil.
Pedro Tadao Hamamoto FilhoDepartment of Neurology, Psychology, and Psychiatry, Botucatu Medical School, São Paulo State University, Botucatu, São Paulo, Brazil.
Juli Thomaz de SouzaDepartment of Neurology, Psychology, and Psychiatry, Botucatu Medical School, São Paulo State University, Botucatu, São Paulo, Brazil.
Luis Cuadrado MartinDepartment of Internal Medicine, Botucatu Medical School, São Paulo State University, Botucatu, São Paulo, Brazil.
Silméia Garcia Zanati BazanDepartment of Internal Medicine, Botucatu Medical School, São Paulo State University, Botucatu, São Paulo, Brazil.
Gabriel Pinheiro ModoloDepartment of Neurology, Psychology, and Psychiatry, Botucatu Medical School, São Paulo State University, Botucatu, São Paulo, Brazil.
Carlos Clayton Macedo de FreitasDepartment of Neurology, Psychology, and Psychiatry, Botucatu Medical School, São Paulo State University, Botucatu, São Paulo, Brazil.
Edison Iglesias de Oliveira VidalDepartment of Internal Medicine, Botucatu Medical School, São Paulo State University, Botucatu, São Paulo, Brazil.
Rodrigo BazanDepartment of Neurology, Psychology, and Psychiatry, Botucatu Medical School, São Paulo State University, Botucatu, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: We evaluated the extent to which frailty mediated the association between age, poor functional outcomes, and mortality after acute ischemic stroke when patients were treated with brain reperfusion (thrombolytic therapy and/or thrombectomy). Materials and methods: This retrospective cohort study included patients diagnosed with ischemic stroke who had undergone intravenous cerebral reperfusion therapy and/or mechanical thrombectomy. We created a mediation model by analyzing the direct natural effect of an mRS score > 2 and death on age-mediated frailty according to the Frailty Index. Results: We enrolled 292 patients with acute ischemic stroke who underwent brain reperfusion. Their mean age was 67.7 ± 13.1 years. Ninety days after the stroke ictus, 54 (18.5%) participants died, and 83 (28.4%) lived with moderate to severe disability (2 < mRS < 6). In the mediation analysis of the composite outcome of disability (mRS score > 2) or death, frailty accounted for 28% of the total effect of age. The models used to test for the interaction between age and frailty did not show statistically significant interactions for either outcome, and the addition of the interaction did not significantly change the direct or indirect effects, nor did it improve model fit. Conclusion: Frailty mediated almost one-third of the effect of age on the composite outcome of disability or death after acute ischemic stroke.

Indexed as

brain reperfusionfrailtystrokethrombectomythrombolytic therapy

Identifiers

PMID38333676
PMCPMC10850226

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.