Evidence map›Paper›PMID 38333639›Full record

ArticleOncology letters2024

The influence of radiological tumor growth pattern on sino‑nasal health in pituitary adenomas.

Sebastian Walbrodt, Karsten H Wrede, Witold X Chmielewski, Thiemo Florin Dinger, Maximilian Schüβler, Cornelius Deuschl, Mehdi Chihi, Hanah Hadice Gull, Ramazan Jabbarli, Marvin Darkwah Oppong and 7 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
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Article in Oncology letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Sebastian WalbrodtDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, D‑45147 Essen, Germany.
Karsten H WredeDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, D‑45147 Essen, Germany.
Witold X ChmielewskiDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, D‑45147 Essen, Germany.
Thiemo Florin DingerDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, D‑45147 Essen, Germany.
Maximilian SchüβlerInstitute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, D‑45147 Essen, Germany.
Cornelius DeuschlInstitute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, D‑45147 Essen, Germany.
Mehdi ChihiDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, D‑45147 Essen, Germany.
Hanah Hadice GullDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, D‑45147 Essen, Germany.
Ramazan JabbarliDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, D‑45147 Essen, Germany.
Marvin Darkwah OppongDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, D‑45147 Essen, Germany.
Annika LenkeitDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, D‑45147 Essen, Germany.
Anne-Kathrin UerschelsDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, D‑45147 Essen, Germany.
Oliver GembruchDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, D‑45147 Essen, Germany.
Ilonka Kreitschmann-AndermahrDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, D‑45147 Essen, Germany.
Björn SchefflerCenter for Translational Neuro- and Behavioral Sciences, University of Duisburg-Essen, D‑45147 Essen, Germany.
Ulrich SureDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, D‑45147 Essen, Germany.
Yahya AhmadipourDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, D‑45147 Essen, Germany.
University of Duisburg-Essen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pituitary adenomas are one of the most common mass lesions of the brain and are associated with a reduced quality of life. While transnasal and transsphenoidal endoscopic approaches are considered to deliver similar recovery rates for sino-nasal health (SNH), the impact of radiological tumor growth patterns on SNH has not been evaluated. In the present study, the influence of radiological tumor growth on SNH was examined before and after endoscopic transsphenoidal tumor resection. Patient data were prospectively collected between August 1, 2016 and August 31, 2022. The Knosp and Hardy classifications were used to dichotomize pituitary adenoma lesions into low- and high-graded lesions. SNH was assessed shortly before surgery and at follow-up examinations 3-6 months after operation using the Sino-Nasal Outcome Test for Neurosurgery (SNOT-NC) questionnaire. Fully completed SNOT-NC questionnaires were collected before and after surgery from a total of 101 patients. Independent t-tests showed significantly higher rates of deterioration after surgery in patients with Knosp low-graded lesions compared with those with high-graded tumors for the SNOT-NC total score P=0.048, nasal discomfort P=0.034, sleep problems P=0.024 and visual impairment P=0.042. Pre- and post-operative comparisons for the Knosp low-graded tumor cohort showed an increase of nasal discomfort (P=0.004), while the Knosp high-graded tumor cohort reported decreased visual impairment (P=0.016) after surgery. Assessing the Hardy classification, increased nasal discomfort was reported in patients with high-graded infrasellar tumors after surgery (P=0.046). Growth characteristics of pituitary adenomas based on Knosp and Hardy classifications may influence SNH. Patients with less invasive lesions were revealed to be more prone to experiencing a decrease in SNH, which went beyond the assumed deterioration of 1-3 months. These findings indicate the importance of detailed information regarding SNH as part of every pre-operative patient briefing.

Indexed as

Hardy classificationKnosp classificationpituitary adenomasino-nasal healthtumor growth

Identifiers

PMID38333639
PMCPMC10851331
OpenAlexW4391271798

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.