Evidence map›Paper›PMID 38333197›Full record

ArticleRSC chemical biology2024

Bioluminescent detection of viral surface proteins using branched multivalent protein switches.

Alexander Gräwe, Cindy M Spruit, Robert P de Vries, Maarten Merkx

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC chemical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Alexander GräweLaboratory of Protein Engineering, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology Eindhoven The Netherlands m.merkx@tue.nl.ORCID https://orcid.org/0000-0003-2892-278X
Cindy M SpruitUtrecht Institute for Pharmaceutical Sciences, Department of Chemical Biology and Drug Discovery Utrecht The Netherlands.ORCID https://orcid.org/0000-0001-6570-7910
Robert P de VriesUtrecht Institute for Pharmaceutical Sciences, Department of Chemical Biology and Drug Discovery Utrecht The Netherlands.ORCID https://orcid.org/0000-0002-1586-4464
Maarten MerkxLaboratory of Protein Engineering, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology Eindhoven The Netherlands m.merkx@tue.nl.ORCID https://orcid.org/0000-0001-9484-3882
Eindhoven University of Technology · NLPharmo Institute · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fast and reliable virus diagnostics is key to prevent the spread of viruses in populations. A hallmark of viruses is the presence of multivalent surface proteins, a property that can be harnessed to control conformational switching in sensor proteins. Here, we introduce a new sensor platform (dark-LUX) for the detection of viral surface proteins consisting of a general bioluminescent framework that can be post-translationally functionalized with separately expressed binding domains. The platform relies on (1) plug-and-play bioconjugation of different binding proteins

Identifiers

PMID38333197
PMCPMC10849123
OpenAlexW4388934775

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.