ArticleEcology and evolution2024
Experimental evolution of hybrid populations to identify Dobzhansky-Muller incompatibility loci.
Article in Ecology and evolution, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Genomic incompatibilities are persistent barriers when speciation happens with gene flow in Formica ants.Molecular biology and evolution · 2026Article
- Evolution of Hybrid Inviability Associated With Chromosome Fusions.Molecular ecology · 2025Article
- Beyond Haldane's rule: Sex-biased hybrid dysfunction for all modes of sex determination.eLife · 2024Review
- Experimental evolution of hybrid populations to identify Dobzhansky-Muller incompatibility loci.Ecology and evolution · 2024Article
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2 authors.
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Abstract
Epistatic interactions between loci that reduce fitness in interspecies hybrids, Dobzhansky-Muller incompatibilities (DMIs), contribute genetically to the inviability and infertility within hybrid populations. It remains a challenge, however, to identify the loci that contribute to DMIs as causes of reproductive isolation between species. Here, we assess through forward simulation the power of evolve-and-resequence (E&R) experimental evolution of hybrid populations to map DMI loci. We document conditions under which such a mapping strategy may be most feasible and demonstrate how mapping power is sensitive to biologically relevant parameters such as one-way versus two-way incompatibility type, selection strength, recombination rate, and dominance interactions. We also assess the influence of parameters under direct control of an experimenter, including duration of experimental evolution and number of replicate populations. We conclude that an E&R strategy for mapping DMI loci, and other cases of epistasis, can be a viable option under some circumstances for study systems with short generation times like
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