Evidence map›Paper›PMID 38332917›Full record

ArticleFrontiers in immunology2023

Investigating the shared genetic architecture between hypothyroidism and rheumatoid arthritis.

Zhifang Peng, Weiping Huang, Mengjun Tang, Binbin Chen, Renqi Yang, Qing Liu, Chaoshui Liu, Panpan Long

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 4 pooled it
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 4 syntheses or guidelines pooled it, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Zhifang Peng *Center of Genetics, Changsha Jiangwan Maternity Hospital, Changsha, Hunan, China.
Weiping Huang *Teaching and Research Section of Clinical Nursing, Xiangya Hospital of Central South University, Changsha, China.
Mengjun TangDepartment of Orthopedics, The 967th Hospital of Joint Logistic Support Force of People's Liberation Army, Dalian, China.
Binbin ChenCenter of Genetics, Changsha Jiangwan Maternity Hospital, Changsha, Hunan, China.
Renqi YangCenter of Genetics, Changsha Jiangwan Maternity Hospital, Changsha, Hunan, China.
Qing LiuCenter of Genetics, Changsha Jiangwan Maternity Hospital, Changsha, Hunan, China.
Chaoshui LiuHunan Provincial Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, the "Double-First Class" Application Characteristic Discipline of Hunan (Pharmaceutical Science), Changsha Medical University, Changsha, China.
Panpan LongCenter of Genetics, Changsha Jiangwan Maternity Hospital, Changsha, Hunan, China.
Changsha Hospital for Maternal and Child Health Care · CNChangsha Medical University · CNXiangya Hospital Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: There is still controversy regarding the relationship between hypothyroidism and rheumatoid arthritis (RA), and there has been a dearth of studies on this association. The purpose of our study was to explore the shared genetic architecture between hypothyroidism and RA. Methods: Using public genome-wide association studies summary statistics of hypothyroidism and RA, we explored shared genetics between hypothyroidism and RA using linkage disequilibrium score regression, ρ-HESS, Pleiotropic analysis under a composite null hypothesis (PLACO), colocalization analysis, Multi-Trait Analysis of GWAS (MTAG), and transcriptome-wide association study (TWAS), and investigated causal associations using Mendelian randomization (MR). Results: We found a positive genetic association between hypothyroidism and RA, particularly in local genomic regions. Mendelian randomization analysis suggested a potential causal association of hypothyroidism with RA. Incorporating gene expression data, we observed that the genetic associations between hypothyroidism and RA were enriched in various tissues, including the spleen, lung, small intestine, adipose visceral, and blood. A comprehensive approach integrating PLACO, Bayesian colocalization analysis, MTAG, and TWAS, we successfully identified Conclusions: Our investigation unveiled a shared genetic architecture between these two diseases, providing novel insights into the underlying biological mechanisms and establishing a foundation for more effective interventions.

Indexed as

Arthritis, RheumatoidHypothyroidismBayes TheoremGenome-Wide Association StudyHumansTranscriptomegenome-wide association studieshypothyroidismrheumatoid arthritisshared genetic architectureshared risk genes

Identifiers

PMID38332917
PMCPMC10850220
OpenAlexW4391228264

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.