Evidence map›Paper›PMID 38332911›Full record

ArticleFrontiers in immunology2023

Eva-Maria Wolfschmitt, Josef Albert Vogt, Melanie Hogg, Ulrich Wachter, Nicole Stadler, Thomas Kapapa, Thomas Datzmann, David Alexander Christian Messerer, Andrea Hoffmann, Michael Gröger and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Eva-Maria WolfschmittInstitute for Anesthesiological Pathophysiology and Process Engineering, University Hospital Ulm, Ulm, Germany.
Josef Albert VogtInstitute for Anesthesiological Pathophysiology and Process Engineering, University Hospital Ulm, Ulm, Germany.
Melanie HoggInstitute for Anesthesiological Pathophysiology and Process Engineering, University Hospital Ulm, Ulm, Germany.
Ulrich WachterInstitute for Anesthesiological Pathophysiology and Process Engineering, University Hospital Ulm, Ulm, Germany.
Nicole StadlerInstitute for Anesthesiological Pathophysiology and Process Engineering, University Hospital Ulm, Ulm, Germany.
Thomas KapapaClinic for Neurosurgery, University Hospital Ulm, Ulm, Germany.
Thomas DatzmannClinic for Anesthesia and Intensive Care, University Hospital Ulm, Ulm, Germany.
David Alexander Christian MessererInstitute for Anesthesiological Pathophysiology and Process Engineering, University Hospital Ulm, Ulm, Germany.
Andrea HoffmannInstitute for Anesthesiological Pathophysiology and Process Engineering, University Hospital Ulm, Ulm, Germany.
Michael GrögerInstitute for Anesthesiological Pathophysiology and Process Engineering, University Hospital Ulm, Ulm, Germany.
Franziska MünzInstitute for Anesthesiological Pathophysiology and Process Engineering, University Hospital Ulm, Ulm, Germany.
René MathieuClinic for Neurosurgery, Bundeswehrkrankenhaus, Ulm, Germany.
Simon MayerClinic for Neurosurgery, Bundeswehrkrankenhaus, Ulm, Germany.
Tamara MerzInstitute for Anesthesiological Pathophysiology and Process Engineering, University Hospital Ulm, Ulm, Germany.
Pierre AsfarDépartement de Médecine Intensive - Réanimation et Médecine Hyperbare, Centre Hospitalier Universitaire, Angers, France.
Enrico CalziaInstitute for Anesthesiological Pathophysiology and Process Engineering, University Hospital Ulm, Ulm, Germany.
Peter RadermacherInstitute for Anesthesiological Pathophysiology and Process Engineering, University Hospital Ulm, Ulm, Germany.
Fabian ZinkInstitute for Anesthesiological Pathophysiology and Process Engineering, University Hospital Ulm, Ulm, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Supplementation with increased inspired oxygen fractions has been suggested to alleviate the harmful effects of tissue hypoxia during hemorrhagic shock (HS) and traumatic brain injury. However, the utility of therapeutic hyperoxia in critical care is disputed to this day as controversial evidence is available regarding its efficacy. Furthermore, in contrast to its hypoxic counterpart, the effect of hyperoxia on the metabolism of circulating immune cells remains ambiguous. Both stimulating and detrimental effects are possible; the former by providing necessary oxygen supply, the latter by generation of excessive amounts of reactive oxygen species (ROS). To uncover the potential impact of increased oxygen fractions on circulating immune cells during intensive care, we have performed a Methods: Swine underwent resuscitation after 2 h of ASDH and HS up to a maximum of 48 h after HS. Animals received normoxemia (P Results: Conclusion: In a model of resuscitated porcine ASDH and HS, we saw that ventilation with increased inspiratory O

Indexed as

Hematoma, Subdural, AcuteHyperoxiaShock, HemorrhagicAnimalsBayes TheoremCitric Acid CycleGlucoseGlutamineGranulocytesMetabolic Flux AnalysisOxygenSuperoxidesSwineGlucoseGlutamineOxygenSuperoxidesBayesian modelingglucose metabolismglutamine utilizationhyperoxiaimmunometabolismmass isotopomer distributionperipheral blood mononuclear cellsreactive oxygen species

Identifiers

PMID38332911
PMCPMC10850868

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.