Evidence map›Paper›PMID 38332747›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2024

Gene-environment interactions: Epstein-Barr virus infection and risk of pediatric-onset multiple sclerosis.

Amin Ziaei, Olivia Solomon, T Charles Casper, Michael Waltz, Bianca Weinstock-Guttman, Greg Aaen, Yolanda Wheeler, Jennifer Graves, Leslie Benson, Mark Gorman and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Epstein-Barr Virus in Multiple Sclerosis: Past, Present, and Future.Neurology(R) neuroimmunology & neuroinflammation · 2025
    Review
  4. Article
  5. Review
  6. A narrative review of genetic and environmental factors and risk for multiple sclerosis. The design of the Italian multicentric PEDIGREE study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Amin ZiaeiUniversity of California San Francisco, San Francisco, CA, USA/Department of Pathology & Laboratory Medicine, University of California, Irvine Medical Center (UCIMC), Orange, CA, USA.
Olivia SolomonDivision of Epidemiology and Genetic Epidemiology and Genomics Laboratory, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
T Charles CasperThe University of Utah, Salt Lake City, UT, USA.
Michael WaltzThe University of Utah, Salt Lake City, UT, USA.
Bianca Weinstock-GuttmanBuffalo General Hospital, State University of New York at Buffalo, Buffalo, NY, USA.ORCID 0000-0001-6732-151X
Greg AaenLoma Linda University Children's Hospital, Loma Linda, CA, USA.
Yolanda WheelerThe University of Alabama at Birmingham, Birmingham, AL, USA.
Jennifer GravesUniversity of California San Diego, San Diego, CA, USA.
Leslie BensonPediatric Multiple Sclerosis and Related Disorders Program, Boston Children's Hospital, Boston, MA, USA.
Mark GormanPediatric Multiple Sclerosis and Related Disorders Program, Boston Children's Hospital, Boston, MA, USA.
Mary RenselCleveland Clinic, Cleveland, OH, USA.ORCID 0000-0001-9613-8394
Soe MarWashington University in St. Louis, St. Louis, MO, USA.
Tim LotzeTexas Children's Hospital, Houston, TX, USA.
Benjamin GreenbergThe University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-2091-8201
Tanuja ChitnisBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-9897-4422
Amy T WaldmanDivision of Child Neurology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Lauren KruppNew York University Medical Center, New York, NY, USA.ORCID 0000-0001-7003-807X
Judith A JamesOklahoma Medical Research Foundation, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Janace HartUniversity of California San Francisco, San Francisco, CA, USA.
Lisa F BarcellosDivision of Epidemiology and Genetic Epidemiology and Genomics Laboratory, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Emmanuelle WaubantUniversity of California San Francisco, San Francisco, CA, USA.

Funding

Oklahoma ACE: Molecular Destruction of Autoimmune Disease to Aid Clinical Trail SuccessUM1AI144292 · NIAID · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI JUDITH A JAMES · 2019 to 2026
$3.3M
Environmental and genetic risk factors for pediatric MSR01NS071463 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WAUBANT, EMMANUELLE LAURENCE · 2010 to 2015
$2.8M
NIAID NIH HHS UM1 AI144292NINDS NIH HHS R01 NS071463
6 · The paper itself

Abstract

BACKGROUND AND

objectivePrior Epstein-Barr virus (EBV) infection is associated with an increased risk of pediatric-onset multiple sclerosis (POMS) and adult-onset multiple sclerosis (MS). It has been challenging to elucidate the biological mechanisms underlying this association. We examined the interactions between candidate human leukocyte antigen (HLA) and non-HLA variants and childhood EBV infection as it may provide mechanistic insights into EBV-associated MS.

methodsCases and controls were enrolled in the Environmental and Genetic Risk Factors for Pediatric MS study of the US Network of Pediatric MS Centers. Participants were categorized as seropositive and seronegative for EBV-viral capsid antigen (VCA). The association between prior EBV infection and having POMS was estimated with logistic regression. Interactions between EBV serostatus, major HLA MS risk factors, and non-HLA POMS risk variants associated with response to EBV infection were also evaluated with logistic regression. Models were adjusted for sex, age, genetic ancestry, and the mother's education. Additive interactions were calculated using relative risk due to interaction (RERI) and attributable proportions (APs).

resultsA total of 473 POMS cases and 702 controls contributed to the analyses. Anti-VCA seropositivity was significantly higher in POMS cases compared to controls (94.6% vs 60.7%,

conclusionWe report evidence for interactions between childhood EBV infection and

Indexed as

Epstein-Barr Virus InfectionsMultiple SclerosisAdultAntibodiesChildHerpesvirus 4, HumanHLA-DRB1 ChainsHumansRisk FactorsAntibodiesHLA-DRB1 ChainsCD68DRB1*15Epstein–Barr virusgene–environment interactionmultiple sclerosisPediatric onset

Identifiers

PMID38332747
PMCPMC11093131

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.